446-59-3

Basic information

• Product Name: 2-Bromo-3-fluoroanisole
• Synonyms: BENZENE,2-BROMO-1-FLUORO-3-METHOXY;REF DUPL: 2-bromo-3-fluoroanisole;2-Bromo-1-fluoro-3-methoxybenzene, 2-Bromo-3-fluorophenyl methyl ether;Bromo-3-fluoro anisole;2-BROMO-3-FLUOROANISOLE;2-Bromo-1-fluoro-3-methoxy-benzene;2-Bromo-3-fluoroanisole 99%;2-Bromo-3-fluoroanisole99%
• CAS NO: 446-59-3
• Molecular Formula: C₇H₆BrFO
• Molecular Weight: 205.02
• Product Categories: Aromatic Halides (substituted)
• Mol File: 446-59-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 189.2 °C at 760 mmHg
• Flash Point: 81.1 °C
• Appearance: /
• Density: 1.531 g/cm³
• Vapor Pressure: 0.577mmHg at 25°C
• Refractive Index: 1.532
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Bromo-3-fluoroanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-3-fluoroanisole(446-59-3)
• EPA Substance Registry System: 2-Bromo-3-fluoroanisole(446-59-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 446-59-3(Hazardous Substances Data)

Usage

General Description

2-Bromo-3-fluoroanisole is a chemical compound that falls under the category of organobromine compounds, specifically aromatic bromine compounds. It is also known as 2-Bromo-3-Fluoro-1-Methoxybenzene, with the molecular formula C7H6BrFO. 2-Bromo-3-fluoroanisole has the molecular weight of 205.025 g/mol. As an organic compound, it carries bromine and fluorine elements, along with being a derivative of anisole due to the methoxy group attached to the aromatic ring. It is typically used in the field of organic synthesis, serving as an intermediate in the production of more complex organic compounds.

InChI:InChI=1/C7H8FNO/c1-10-6-4-2-3-5(8)7(6)9/h2-4H,9H2,1H3

Upstream product

• 443-81-2 2-bromo-3-fluorophenol 
• 74-88-4 methyl iodide 
• 641-49-6 1-fluoro-3-methoxy-2-nitrobenzene 
• 456-49-5 1-fluoro-3-methoxybenzene 
• 446-61-7 2-fluoro-6-methoxyphenylamine 

Downstream Products

• 75626-21-0 C₉H₁₂BFO₃ 
• 286836-05-3 7-bromo-6-fluorobenzofuran 
• 286836-03-1 7-bromo-6-methoxybenzofuran 
• 1155877-70-5 3-bromo-2-fluoro-4-methoxybenzaldehyde 
• 53308-23-9 5-methoxy-1,4-dihydro-1,4-methanonaphthalene 
• 113028-78-7 1-(2-fluoro-6-methoxyphenyl)piperazine 
• 73943-41-6 2-fluoro-6-methoxyphenol 

Relevant articles and documents

Phenyl acetate derivatives, fluorine-substituted on the phenyl group, as rapid recovery hypnotic agents with reflex depression

We report the synthesis of novel, potentially hypnotic fluorine-substituted phenyl acetate derivatives. We describe the structure-activity relationship that led us to the promising derivative: ethyl 2-(4-(2-(diethylamino)-2-oxoethoxy)-5-ethoxy-2-fluorophenyl) acetate (55). The unique pharmacological features of compound 55 are its relatively high affinity for the GABAA receptor, together with a unique affinity for the NMDA receptor, different to propanidid and AZD3043. In animal models, compound 55 showed stronger hypnotic potency and longer duration of LORR than propanidid and AZD3043, but also maintained a rapid recovery time to walking and behavioral recovery. In particular, compound 55 displayed reflex depression during infusion.

107. Substitution electrophile aromatique dans l'anhydride sulfureux liquide. Etude cinetique de la reaction de bromination d'anisoles monosubstitues. Transmission des effets electroniques et caracteristiques de l'etat de transition

Reactivity-structure correlations for anisole and eleven of its substituted derivatives established from bromination rate constants in liquid SO2, unlike observations in water, show the reaction to be highly sensitive to substituent effects, (ρ+H2O = -7.1; ρ+SO2 = -10.51).This result is ascribed to the solvation of the methoxy group which decreases the conjugation of para-substituted (ρ+O = -9.70) compared to that of ortho-substituted derivatives (ρ+p = -8.86).The highly solvated transition state lies far from reactants on the reaction coordinate and the positive charge developed in this state is nearly unity.