446-63-9

Basic information

• Product Name: 1-(3-broMophenyl)-2,2,2-trifluoroethanol
• Synonyms: 1-(3-broMophenyl)-2,2,2-trifluoroethanol;1-(5-bromopyridin-3-yl)-2,2,2-trifluoroethan-1-ol
• CAS NO: 446-63-9
• Molecular Formula: C₈H₆BrF₃O
• Molecular Weight: 255.0318496
• Mol File: 446-63-9.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(3-broMophenyl)-2,2,2-trifluoroethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-broMophenyl)-2,2,2-trifluoroethanol(446-63-9)
• EPA Substance Registry System: 1-(3-broMophenyl)-2,2,2-trifluoroethanol(446-63-9)

Safety Data

• Hazardous Substances Data: 446-63-9(Hazardous Substances Data)

Usage

General Description

1-(3-bromophenyl)-2,2,2-trifluoroethanol is a chemical compound that is primarily used as a reagent in organic synthesis. It is characterized by its trifluoromethyl and bromine substituents attached to a phenyl ring, and a tertiary alcohol functional group. 1-(3-broMophenyl)-2,2,2-trifluoroethanol has been studied for its potential use as an anesthetic due to its structural resemblance to other anesthetics, but its use in this capacity has not been widely adopted. It is also used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. Additionally, it has potential applications in the production of agrochemicals and other specialty chemicals. However, safety precautions should be taken when handling this compound, as it is toxic and poses a risk of skin and eye irritation.

Upstream product

• 407-38-5 2,2,2-trifluoroethyl trifluoroacetate 
• 591-18-4 1-Bromo-3-iodobenzene 
• 655-26-5 m-bromotrifluoroacetone 
• 3132-99-8 m-bromobenzoic aldehyde 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 655-26-5 m-bromotrifluoroacetone 
• 58174-57-5 m-bromo-1,2,2-trifluorostyrene 

Relevant articles and documents

SUBSTITUTED TRICYCLIC COMPOUNDS

Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, Formula (I) wherein, ring A, R1 to R5, X, Y, m, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.

Palladium-Catalyzed Suzuki–Miyaura Cross-Coupling of Secondary α-(Trifluoromethyl)benzyl Tosylates

A palladium-catalyzed C(sp3)?C(sp2) Suzuki–Miyaura cross-coupling of aryl boronic acids and α-(trifluoromethyl)benzyl tosylates is reported. A readily available, air-stable palladium catalyst was employed to access a wide range of functionalized 1,1-diaryl-2,2,2-trifluoroethanes. Enantioenriched α-(trifluoromethyl)benzyl tosylates were found to undergo cross-coupling to give the corresponding enantioenriched cross-coupled products with an overall inversion in configuration. The crucial role of the CF3 group in promoting this transformation is demonstrated by comparison with non-fluorinated derivatives.

Enzymatic resolution by CALB of organofluorine compounds under conventional condition and microwave irradiation

Enzymatic kinetic resolution of organofluorine rac-alcohols by CALB yielded ( )-(R)-2,2,2-trifluoro-1- phenylethanol (2a), ()-(R)-1-(3-bromophenyl)-2,2,2- trifluoroethanol (2b), ()-(R)-1-(4-bromophenyl)- 2,2,2-trifluoroethanol (2c), ()-(S)-1-(2,4,5-trifluorophenyl)ethanol (2d), (+)-(S)-2,2,2-trifluoro-1- phenylethyl acetate (3a), (+)-(S)-1-(3-bromophenyl)-2,2,2-trifluoroethyl acetate (3b), (+)-(S)-1-(4- bromophenyl)-2,2,2-trifluoroethyl acetate (3c) and (+)-(R)-1-(2,4,5-trifluorophenyl)ethyl acetate (3d) in high enantiomeric excess (up to >99% ee). The reactions were conducted under conventional conditions (orbital shaking) and microwave irradiation in toluene and vinyl acetate as acylating agent. The CALB showed excellent selectivities and good yields in the transesterification of fluorinated aromatic compounds.