446292-04-2Relevant articles and documents
Synthesis, Characterization, and Biological Evolution of New Pyrazole Derivatives of 4-(4-Aminophenyl)morpholin-3-one through Ugi Reaction
Joshi, Harsh H.,Parsania, M. V.
, p. 247 - 253 (2021/08/03)
A new heterocyclic library was synthesized using multicomponent reactions (MCRs). A green strategy during which a set of molecules with an excellent diversity is generated with a minimum of synthetic effort, time, and by-products formation. This new series prepared using the Ugi MCRs in which aldehyde, amine, acid, and isocyanide reacts to make α-bisamide. During this work, we practice the Ugi reaction to synthesize an extremely functionalized heterocyclic library which was characterized and tested for biological evaluation. This innovative synthetic route involves for pyrazole derivatives of 4-(4-aminophenyl)morpholin-3-one by Ugi four component reaction and methanol as a solvent in good yield and high purity. All the produced compounds of library were characterized using 1H-NMR, IR, and mass spectroscopic methods.
Synthesis method of 4-(4-aminophenyl)-3-morpholone
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, (2021/06/12)
The invention provides a synthesis method of 4-(4-aminophenyl)-3-morpholone. The method comprises the following steps: condensing p-halonitrobenzene and morpholine which are used as starting materials to generate 4-(4-nitrophenyl) morpholine, oxidizing 4-(4-nitrophenyl) morpholine by taking a halite or chlorine dioxide as an oxidizing agent and controlling the pH value of a reaction system to be less than 7 to generate 4-(4-nitrophenyl)-3-morpholone, and finally reducing to generate the target product 4-(4-aminophenyl)-3-morpholone. The synthesis method of 4-(4-aminophenyl)-3-morpholinone provided by the invention has the advantages of greenness, high efficiency, easiness in industrial application and the like.
A high-purity 4 - (4 - aminophenyl) morpholine -3 - ketone (by machine translation)
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Paragraph 0077; 0078, (2019/03/15)
The invention relates to a low-cost, high-purity of 4 - (4 - aminophenyl) morpholine - 3 - one (II) of the preparation method. The use of hydroxy acetonitrile and 1, 2 - dihalo substituted ethane in the reaction process for preparing halogenated ethyl oxygen radical second grade nitrile IV, then with the para-nitroaniline III substituted reaction, acid lower ring becomes a 4 - (4 - nitrophenyl) morpholine - 3 - ketone V, 4 - (4 - nitrophenyl) morpholine - 3 - ketone V obtained by hydrogenating and reducing 4 - (4 - aminophenyl) morpholine - 3 - one II. The present invention the used raw materials are cheap and easily obtained, and the cost is low; the process route is simple, safety and environmental protection; the design of each step the reaction selectivity is high, high yield, high purity for the 4 - (4 - aminophenyl) morpholine - 3 - ketone preparation provides a guarantee, to industrial production of high-purity [...]. (by machine translation)