447-03-0

Basic information

• Product Name: 2-(4-fluorophenyl)-3-oxobutyronitrile
• Synonyms: 2-(4-fluorophenyl)-3-oxobutyronitrile;α-Acetyl-4-fluorobenzeneacetonitrile;1-Cyano-1-(4-fluorophenyl)propan-2-one;2-(4-fluorophenyl)-3-oxobutanenitrile ;a-Acetyl-4-fluoro-benzeneacetonitrile
• CAS NO: 447-03-0
• Molecular Formula: C₁₀H₈FNO
• Molecular Weight: 177.1750232
• EINECS: 207-178-0
• Mol File: 447-03-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 90 °C
• Boiling Point: 237.7°Cat760mmHg
• Flash Point: 97.5°C
• Appearance: /
• Density: 1.175
• Vapor Pressure: 0.0442mmHg at 25°C
• Refractive Index: 1.509
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-fluorophenyl)-3-oxobutyronitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-3-oxobutyronitrile(447-03-0)
• EPA Substance Registry System: 2-(4-fluorophenyl)-3-oxobutyronitrile(447-03-0)

Safety Data

• Hazardous Substances Data: 447-03-0(Hazardous Substances Data)

Usage

General Description

2-(4-fluorophenyl)-3-oxobutyronitrile is a chemical compound with the molecular formula C10H7NOCl. It is a nitrile derivative and contains a fluorophenyl group, which gives it its characteristic properties. 2-(4-fluorophenyl)-3-oxobutyronitrile is used in organic synthesis and pharmaceutical research, particularly in the development of potential drug candidates. Its unique structure and reactivity make it a valuable building block for the synthesis of more complex organic molecules. Additionally, its nitrile functional group makes it a versatile precursor for the preparation of various compounds with diverse applications in the chemical industry. Overall, 2-(4-fluorophenyl)-3-oxobutyronitrile is an important intermediate in organic chemistry with potential applications in drug development and other fields.

InChI:InChI=1/C10H8FNO/c1-7(13)10(6-12)8-2-4-9(11)5-3-8/h2-5,10H,1H3

Upstream product

• 459-22-3 4-fluorophenylacetonitrile 
• 141-78-6 ethyl acetate 

Downstream Products

• 702709-77-1 4-(4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine 
• 863400-29-7 2-(4-fluorophenyl)-3-methoxybut-2-ene nitrile 
• 1160169-14-1 (E)-3-amino-2-(4-fluorophenyl)but-2-enenitrile 
• 1404447-03-5 3-(4-fluorophenyl)-2-methyl-5-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 62538-16-3 4-(4-fluorophenyl)-3-methyl-1H-pyrazol-5-amine 
• 1404447-07-9 5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-fluorophenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1404449-60-0 3-(4-fluorophenyl)-2-methylpyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione 
• 1404449-61-1 5,7-dichloro-3-(4-fluorophenyl)-2-methylpyrazolo[1,5-a]pyrimidine 
• 1404449-62-2 5-chloro-3-(4-fluorophenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1404447-09-1 3-(4-fluorophenyl)-2-methyl-5-(quinolin-6-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 

Relevant articles and documents

NEW ANTI-MALARIAL AGENTS

The present invention is related to a use of pyrazole derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to pyrazole derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

Use of Pyrazolo(1,5A)Pyrimidin-7-YL Amine Derivatives in the Treatment of Neurological Disorders

The invention relates to methods of using the compounds of the invention, including pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof, as well as pharmaceutical compositions comprising the same, in the treatment of Eph receptor-related (e.g., neurological) injuries and disorders. The invention also relates to modulating the activity of an Eph receptor in a cell, stimulating neural regeneration, and reversing neuronal degeneration, by administering a compound of the invention to a cell or subject in an effective amount.

Synthesis of N-substituted indole derivatives via PIFA-mediated intramolecular cyclization

(Chemical Equation Presented) A variety of N-arylated and N-alkylated indole derivatives were synthesized by way of a phenyliodine bis(trifluoroacetate) (PIFA)-mediated intramolecular cyclization. This novel method allows for the construction of an indole skeleton by joining the N-atom on the side chain to the benzene ring at the last synthetic step. Other novel pyrrole-fused aromatic compounds can also be achieved by this method.