448-38-4

Basic information

• Product Name: 4-chloro-2-nitro-1-(trifluoroMethoxy)benzene
• Synonyms: 4-chloro-2-nitro-1-(trifluoroMethoxy)benzene;5-Chloro-2-(Trifluoromethoxy)nitrobenzene;4-Chloro-2-nitro-1-(trifluoromethoxy)
• CAS NO: 448-38-4
• Molecular Formula: C₇H₃ClF₃NO₃
• Molecular Weight: 241.5518296
• Mol File: 448-38-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-chloro-2-nitro-1-(trifluoroMethoxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2-nitro-1-(trifluoroMethoxy)benzene(448-38-4)
• EPA Substance Registry System: 4-chloro-2-nitro-1-(trifluoroMethoxy)benzene(448-38-4)

Safety Data

• Hazardous Substances Data: 448-38-4(Hazardous Substances Data)

Usage

General Description

4-chloro-2-nitro-1-(trifluoromethoxy)benzene is a chemical compound that belongs to the class of nitrobenzenes. The compound consists of a benzene ring with a chlorine atom and a nitro group attached at the 4 and 2 positions, respectively, and a trifluoromethoxy group attached at the 1 position. It is a yellow solid at room temperature and is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. The compound is known to be toxic if ingested, inhaled, or comes into contact with the skin, and thus, proper handling and storage procedures should be followed to ensure safety.

Upstream product

• 461-81-4 1-chloro-4-(trifluoromethoxy)benzene 

Downstream Products

• 326-64-7 2-amino-4-chlorotrifluoro-methoxybenzene 
• 1261791-19-8 4-chloro-2(-3)-nitrotrifluoro-methoxybenzene 

Relevant articles and documents

Co-production preparation method of o-amino trifluoromethoxy benzene and m-amino trifluoromethoxy benzene

The invention discloses a co-production preparation method of o-amino trifluoromethoxybenzene and m-amino trifluoromethoxybenzene, and belongs to the technical field of fine chemical engineering. Thepreparation method comprises the following steps: (1) nitration reaction: carrying out nitration reaction on 4-chlorine-trifluoromethoxybenzene to obtain a mixture of 4-chlorine-2-nitro- trifluoromethoxy benzene and 4-chlorine-3-nitro-trifluoromethoxybenzene; (2) reduction and dechlorination: carrying out reduction and dechlorination on the mixture of the 4-chloro-2-nitro-trifluoromethoxybenzene and the 4-chloro-3-nitro-trifluoromethoxybenzene to obtain o-amino trifluoromethoxybenzene and m-amino trifluoromethoxybenzene; and (3) rectification separation: separating the o-amino trifluoromethoxybenzene from the m-amino trifluoromethoxybenzene through rectification so as to realize co-production. The method is low in cost and high in yield, two useful chemical products are obtained at the same time, the process is simple, and industrial production is easy to achieve.

LONIDAMINE ANALOGUES FOR FERTILITY MANAGEMENT

Fertility management can include: administering to the subject one or more doses of a compound according to Formula I so as to reduce fertility in the subject. Fertility management can also include administering an effective amount of the compound to: impair Sertoli cell function in a male subject; inhibit spermatogenesis in the subject; reduce testis weight in the subject; reduce ovary weight in a female subject; reduce serum progesterone in the female subject; impair ovarian follicle function in the female subject; causing reversible fertility in the subject. In order to return fertility, the method can include ceasing administration of the compound to the subject so as to return fertility in the subject. The compound can be administered for irreversibly sterilizing the subject.

Lonidamine analogues and their use in male contraception and cancer treatment

Novel compounds useful for inhibiting spermatogenesis and cancer treatment, and in particular as inhibitors of heat shock proteins and/or elongation factor 1 alpha.