452-81-3

Basic information

• Product Name: 2-FLUORO-4-METHYLPHENOL
• Synonyms: 2-Fluoro-p-cresol;2-FLUORO-4-METHYLPHENOL;3-Fluoro-4-hydroxytoluene, 2-Fluoro-p-cresol
• CAS NO: 452-81-3
• Molecular Formula: C₇H₇FO
• Molecular Weight: 126.13
• Product Categories: Aromatic Phenols;Miscellaneous
• Mol File: 452-81-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 173°Cat760mmHg
• Flash Point: 66.4°C
• Appearance: /
• Density: 1.164g/cm³
• Vapor Pressure: 0.967mmHg at 25°C
• Refractive Index: 1.513
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 9.01±0.18(Predicted)
• CAS DataBase Reference: 2-FLUORO-4-METHYLPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-4-METHYLPHENOL(452-81-3)
• EPA Substance Registry System: 2-FLUORO-4-METHYLPHENOL(452-81-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-34-22
• Safety Statements: 26-36/37/39
• RIDADR: 2922
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 452-81-3(Hazardous Substances Data)

Usage

General Description

2-Fluoro-4-methylphenol, also known as 4-Methyl-2-fluorophenol or (4-Methyl-2-fluorophenyl) hydroxy, is a chemical compound that belongs to the family of Fluorophenols. Its molecular formula is C7H7FO and it is known for its phenolic structure. This chemical is generally used in the field of organic synthesis where it acts as a building block to create more complex molecules. Its properties include a clear to yellow liquid form, a strong aroma, and it is known to be harmful if swallowed, inhaled, or when it comes into contact with the skin. It is typically stored in a cool, dry place under inert gas for preservation purposes. Furthermore, it is categorized under the hazard statements H302 + H312 + H332, indicating its harmful nature when swallowed, comes into contact with skin, or even when inhaled.

InChI:InChI=1/C7H7FO/c1-5-2-3-7(9)6(8)4-5/h2-4,9H,1H3

Upstream product

• 170981-26-7 2-fluoro-4-methylphenylboronic acid 
• 106-44-5 p-cresol 
• 452-80-2 2-fluoro-4-methylaniline 
• 4783-71-5 2-(4-methylphenoxy)pyridine 
• 446-34-4 2-fluoro-4-methyl-1-nitrobenzene 

Downstream Products

• 1443342-79-7 C₁₃H₁₇FO₃ 
• 1072003-84-9 tert-butyl [5-(2-fluoro-4-methylphenoxy)-2-nitrophenyl]methylcarbamate 
• 1427406-95-8 2-fluoro-6-methyl-3-triisopropylsilyloxy-benzoic acid 
• 1427406-96-9 1,3-bis(2-fluoro-6-methyl-3-triisopropylsilyloxyphenyl)urea 
• 1427406-94-7 (2-fluoro-4-methylphenoxy)triisopropyl-silane 
• 765302-76-9 C₁₃H₁₀BrFO 
• 32862-25-2 C₁₅H₁₄FNO₄ 
• 32862-24-1 C₁₄H₁₂FNO₄ 
• 2967-69-3 (2-fluoro-4-methyl-phenoxy)-acetic acid 
• 2070-43-1 2-fluoro-4-methyl-6-nitrophenol 

Relevant articles and documents

Solvent-Free Fluorination of Electron-Rich Aromatic Compounds with F-TEDA-BF4: Toward “Dry” Processes

An effective protocol for the solvent-free fluorination of electron-rich aromatic compounds with 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (F-TEDA-BF4) is described. The protocol allows the easy and efficie

Synthesis of 2 - fluoro phenol compounds

The present invention provides a method for synthetizing a 2-fluoro phenol compound shown in a formula IV. The phenol compound shown in the formula I is prepared into a 2-pyridine oxygroup arene compound shown in a formula II through an Ullmann reaction, the 2-pyridine oxygroup arene compound shown in the formula II is mixed with a palladium catalyst, a fluorinating reagent, an additive and an organic solvent, the mixture is stirred under the temperature of 30-160 DEG C to perform a fluorination reaction to obtain an ortho-position fluoridated 2-pyridine oxygroup arene compound shown in a formula III, and the ortho-position fluoridated 2-pyridine oxygroup arene compound shown in the formula III is prepared into the 2-fluoro phenol compound shown in the formula IV through the action of alkali. The method provided by the present invention has the advantages of mild reaction conditions, simplicity in operations, good substrate adaptability, high fluorination selectivity and the like. The 2-fluoro phenol compound is shown in the figure below.

Fluorination of aromatic compounds with N-fluorobenzenesulfonimide under solvent-free conditions

Reactions of N-fluorobenzenesulfonimide with methylbenzenes, phenols, and phenol ethers were studied under solvent-free conditions. The rate constant ratio for the reactions with mesitylene and durene indicates polar mechanism of the process. Solvent-free fluorination of aromatic compounds with N-fluorobenzenesulfonimide in some cases is more selective than reactions with other N-F reagents in a solvent.