454-65-9 Usage
Description
3-BroMobenzenesulfonyl fluoride is a chemical compound that features a sulfonyl fluoride motif. This motif is known for its ability to act as a connector for the assembly of -SO2linked small molecules with proteins or nucleic acids. 3-BroMobenzenesulfonyl fluoride is significant in the field of click chemistry, offering a complementary approach to using amides and phosphate groups as linkers.
Uses
Used in Chemical Synthesis:
3-BroMobenzenesulfonyl fluoride is used as a connector in chemical synthesis for the assembly of -SO2linked small molecules with proteins or nucleic acids. Its sulfonyl fluoride motif allows for the formation of stable and functional linkages, which can be beneficial in various chemical reactions and the development of new compounds.
Used in Click Chemistry:
In the field of click chemistry, 3-BroMobenzenesulfonyl fluoride is used as a complementary linker to amides and phosphate groups. Its ability to facilitate the formation of -SO2linked small molecules with proteins or nucleic acids expands the range of possible reactions and applications in this area.
Used in Pharmaceutical Development:
3-BroMobenzenesulfonyl fluoride can be utilized in the development of new pharmaceuticals, particularly in the design of drug delivery systems and the synthesis of bioactive molecules. Its unique properties as a sulfonyl fluoride-based connector make it a valuable tool in creating innovative and effective treatments.
Used in Bioconjugation:
3-BroMobenzenesulfonyl fluoride is also used in bioconjugation processes, where it serves as a linker between biological molecules such as proteins or nucleic acids. This allows for the creation of novel bioconjugates with potential applications in research, diagnostics, and therapeutics.
Overall, 3-BroMobenzenesulfonyl fluoride is a versatile chemical compound with a range of applications in various industries, including chemical synthesis, click chemistry, pharmaceutical development, and bioconjugation. Its unique properties as a sulfonyl fluoride-based connector make it a valuable asset in the development of new and innovative products and processes.
Check Digit Verification of cas no
The CAS Registry Mumber 454-65-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,5 and 4 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 454-65:
(5*4)+(4*5)+(3*4)+(2*6)+(1*5)=69
69 % 10 = 9
So 454-65-9 is a valid CAS Registry Number.
454-65-9Relevant articles and documents
Arylsulfonyl fluoride boronic acids: Preparation and coupling reactivity
Lou, Terry Shing-Bong,Willis, Michael C.
, (2020)
We report the efficient and practical syntheses of ortho-, meta, and para-sulfonyl fluoride substituted benzene boronic acids. The syntheses of the para- and meta-isomers commence with the appropriate bromo-substituted benzenesulfonyl chlorides, and the o
Method for preparing aryl sulfonyl fluoride by using aryl hydrazine hydrochloride as raw material
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Paragraph 0078-0082, (2021/11/06)
The invention relates to a method for preparing aryl sulfonyl fluoride by using aryl hydrazine hydrochloride as a raw material. According to the method, aryl sulfonyl fluoride is synthesized by taking the aryl hydrazine hydrochloride as a raw material and adding a sulfur dioxide source and a fluorination reagent under the conditions of copper salt catalysis and alkali promotion through a strategy of insertion and fluorination of free radical sulfur dioxide. Compared with the prior art, the aryl sulfonyl fluoride is synthesized under the oxidation condition, and the influence of air on the reaction is not obvious in an experiment; and the reaction synthesis method is simple, good in selectivity, excellent in yield, mild in reaction condition, short in reaction time and universal to various aryl hydrazine hydrochloride substrates, and the method provides a new thought for synthesis of aryl sulfonyl fluoride.
Arenesulfonyl Fluoride Synthesis via Copper-Catalyzed Fluorosulfonylation of Arenediazonium Salts
Liu, Yongan,Yu, Donghai,Guo, Yong,Xiao, Ji-Chang,Chen, Qing-Yun,Liu, Chao
supporting information, p. 2281 - 2286 (2020/03/13)
We report herein a general and practical copper-catalyzed fluorosulfonylation reaction of a wide range of abundant arenediazonium salts to smoothly prepare various arenesulfonyl fluorides using the 1,4-diazabicyclo[2.2.2]octane-bis(sulfur dioxide) adduct as a convenient sulfonyl source in combination with KHF2 as an ideal fluorine source and without the need for additional oxidants. Interestingly, the electronic character of the arene ring in the starting arenediazonium salts has a significant impact on the reaction mechanistic pathway.
