45438-80-0 Usage
Description
2-Thienylzinc bromide is an organozinc reagent that features a thiophene ring and a zinc bromide moiety. It is a versatile building block in organic synthesis, particularly for the preparation of various heterocyclic compounds and functional materials.
Uses
Used in Pharmaceutical Industry:
2-Thienylzinc bromide is used as a starting material for the synthesis of heteroaryl sulfonamides, which are important intermediates in the development of pharmaceutical compounds with potential therapeutic applications.
Used in Polymer Synthesis:
In the field of polymer chemistry, 2-Thienylzinc bromide serves as a substrate for the synthesis of naphthacenodithiophene-derived polymers. These polymers are utilized in the fabrication of transistor and solar cell devices, contributing to advances in electronic and optoelectronic technologies.
Used in Organic Synthesis:
2-Thienylzinc bromide is employed as an intermediate in the preparation of isoquinoline-derived AICARFT inhibitors. These compounds are of interest in medicinal chemistry for their potential as therapeutic agents.
Overall, 2-Thienylzinc bromide is a valuable reagent in various chemical and materials science applications, enabling the synthesis of complex molecules and functional materials for diverse industries.
Check Digit Verification of cas no
The CAS Registry Mumber 45438-80-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,5,4,3 and 8 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 45438-80:
(7*4)+(6*5)+(5*4)+(4*3)+(3*8)+(2*8)+(1*0)=130
130 % 10 = 0
So 45438-80-0 is a valid CAS Registry Number.
InChI:InChI=1/C4H3S.BrH.Zn/c1-2-4-5-3-1;;/h1-3H;1H;/q-1;;+2/p-1/rC4H3S.BrZn/c1-2-4-5-3-1;1-2/h1-3H;/q-1;+1
45438-80-0Relevant articles and documents
New chemical synthesis of functionalized arylzinc compounds from aromatic or thienyl bromides under mild conditions using a simple cobalt catalyst and zinc dust
Fillon, Hyacinthe,Gosmini, Corinne,Perichon, Jacques
, p. 3867 - 3870 (2007/10/03)
A new chemical method for the preparation of arylzinc intermediates is described in acetonitrile, on the basis of the activation of aryl bromides by low-valent cobalt species arising from the reduction of cobalt halide by zinc dust. This procedure allows for the synthesis of a variety of functionalized aryl- and thienylzinc species in good to excellent yields. The versatility and the simplicity of that original method represent an alternative to most known procedures.
