455-19-6 Usage
Description
4-(Trifluoromethyl)benzaldehyde, also known as 4-(CF3)C6H4CHO, is an organic compound belonging to the family of aromatic aldehydes. It is characterized by the presence of a trifluoromethyl group (-CF3) at the 4-position of the benzene ring and an aldehyde functional group (-CHO) at the 1-position. 4-(Trifluoromethyl)benzaldehyde exhibits clear colorless to yellow liquid properties and is known for its reactivity and versatility in chemical synthesis.
Uses
Used in Pharmaceutical Industry:
4-(Trifluoromethyl)benzaldehyde is used as a key reactant for the synthesis of N,N''-(Arylmethylene)bisamides, which possess cytotoxic activity. These compounds are of significant interest in the development of anticancer agents, targeting various types of cancer cells and exhibiting potential therapeutic benefits in cancer treatment.
The trifluoromethyl group in 4-(Trifluoromethyl)benzaldehyde imparts unique chemical and biological properties to the synthesized compounds, enhancing their overall effectiveness as anticancer agents. The aldehyde functional group allows for further chemical modifications and the formation of a wide range of derivatives with diverse applications in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 455-19-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,5 and 5 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 455-19:
(5*4)+(4*5)+(3*5)+(2*1)+(1*9)=66
66 % 10 = 6
So 455-19-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H5F3O/c9-8(10,11)7-3-1-6(5-12)2-4-7/h1-5H
455-19-6Relevant articles and documents
In alkaline media, Fremy's salt oxidizes alkanols by a hydrogen atom transfer mechanism
De, Piyali,Kumar, Dhurjati Prasad,Mondal, Amit Kumar,Mandal, Pulak Chandra,Mukhopadhyay, Subrata,Banerjee, Rupendranath
, p. 1358 - 1362 (2010)
In aqueous alkali, Fremy's salt (potassium nitrosodisulfonate dimer), homolyses nearly exclusively to the monomer radical anion, nitrosodisulfonate (NDS). In this media, NDS almost quantitatively oxidizes benzyl alcohol (PhCH2OH) to benzaldehyd
A Metal–Organic Framework as a Multiphoton Excitation Regulator for the Activation of Inert C(sp3)?H Bonds and Oxygen
Cai, Junkai,Cai, Wei,Du, Zenggang,Duan, Chunying,He, Cheng,Ji, Guanfeng,Wei, Jianwei,Zhao, Liang
supporting information, (2021/11/27)
The activation and oxidization of inert C(sp3)?H bonds into value-added chemicals affords attractively economic and ecological benefits as well as central challenge in modern chemistry. Inspired by the natural enzymatic transformation, herein,
Radical-mediated aerobic oxidation of substituted styrenes and stilbenes
Aman, Hasil,Chiu, Wei-Hua,Chuang, Gary Jing,Liu, Pin-Heng
supporting information, p. 20103 - 20106 (2021/12/02)
A 2,2-azobis(isobutyronitrile)-catalyzed oxidative cleavage of alkenes with molecular oxygen as the oxidant was described. Carbonyl compounds and oxiranes were obtained in moderate yield under mild conditions. This study provided useful insights into the mechanism of aerobic oxidative cleavage of alkenes.