455-58-3

Basic information

• Product Name: 2-Bromo-6-fluoro-4-nitroaniline
• Synonyms: 2-Bromo-6-fluoro-4-nitroaniline;2-BroMo-6-fluoro-4-nitro-phenylaMine
• CAS NO: 455-58-3
• Molecular Formula: C₆H₄BrFN₂O₂
• Molecular Weight: 235.0105632
• Mol File: 455-58-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 333.0±37.0 °C(Predicted)
• Appearance: /
• Density: 1.896±0.06 g/cm3(Predicted)
• PKA: -2.70±0.20(Predicted)
• CAS DataBase Reference: 2-Bromo-6-fluoro-4-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-6-fluoro-4-nitroaniline(455-58-3)
• EPA Substance Registry System: 2-Bromo-6-fluoro-4-nitroaniline(455-58-3)

Safety Data

• Hazardous Substances Data: 455-58-3(Hazardous Substances Data)

Usage

Description

2-Bromo-6-fluoro-4-nitroaniline is an organic compound with the molecular formula C6H4BrFN2O2. It is characterized by the presence of a bromine atom at the 2nd position, a fluorine atom at the 6th position, and a nitro group at the 4th position on an aniline backbone. 2-Bromo-6-fluoro-4-nitroaniline is known for its versatile chemical properties and reactivity, making it a valuable intermediate in the synthesis of various organic compounds.

Uses

Used in Pharmaceutical Industry:
2-Bromo-6-fluoro-4-nitroaniline is used as an intermediate in the synthesis of phenylenediamines, which are essential building blocks for various pharmaceutical compounds. The process involves the imination of fluoroanilines with DMF (dimethylformamide) followed by amination and elimination with amines. These phenylenediamines are further utilized in the development of drugs with diverse therapeutic applications, such as anti-inflammatory, antimicrobial, and antiviral agents.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-Bromo-6-fluoro-4-nitroaniline serves as a key intermediate for the production of various organic compounds, including dyes, pigments, and polymers. Its unique structural features allow for a wide range of chemical reactions, enabling the creation of novel molecules with specific properties and applications.
Used in Research and Development:
2-Bromo-6-fluoro-4-nitroaniline is also employed in research and development for the exploration of new chemical reactions and the synthesis of novel compounds. Its reactivity and structural diversity make it an attractive candidate for studying reaction mechanisms, optimizing reaction conditions, and developing new synthetic routes to target molecules.

Upstream product

• 369-35-7 2-fluoro-4-nitroaniline 

Downstream Products

• 952664-92-5 2-(3,3-dimethylbut-1-ynyl)-6-fluoro-4-nitrophenylamine 
• 952664-95-8 2-tert-butyl-7-fluoro-1H-indol-5-amine 
• 952664-93-6 N-[2-(3,3-dimethylbut-1-ynyl)-6-fluoro-4-nitrophenyl]-butyramide 
• 952664-94-7 2-tert-butyl-7-fluoro-5-nitro-1H-indole 

Relevant articles and documents

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

Modulators of ATP-binding cassette transporters

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.