455-69-6

Basic information

• Product Name: Methyl 2-Fluoroisonicotinate
• Synonyms: Methyl 2-Fluoroisonicotinate;Methyl 2-fluoropyridine-4-carboxylate;4-Pyridinecarboxylic acid, 2-fluoro-, methyl ester;2-fluoro-4-Pyridinecarboxylic acid methyl ester
• CAS NO: 455-69-6
• Molecular Formula: C7H6FNO2
• Molecular Weight: 155.13
• EINECS: 200-589-5
• Product Categories: Picolinic acid series
• Mol File: 455-69-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 227.7 °C at 760 mmHg
• Flash Point: 93 °C
• Appearance: /
• Density: 1.251 g/mL at 25 °C
• Vapor Pressure: 0.0764mmHg at 25°C
• Refractive Index: n20/D 1.488
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.54±0.10(Predicted)
• CAS DataBase Reference: Methyl 2-Fluoroisonicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-Fluoroisonicotinate(455-69-6)
• EPA Substance Registry System: Methyl 2-Fluoroisonicotinate(455-69-6)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 455-69-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 28, p. 255, 1987 DOI: 10.1016/S0040-4039(00)95700-9

InChI:InChI=1/C7H6FNO2/c1-11-7(10)5-2-3-9-6(8)4-5/h2-4H,1H3

Upstream product

• 186581-53-3 diazomethane 
• 402-65-3 2-fluoropyridine-4-carboxylic acid 
• 461-87-0 2-fluoro-4-methylpyridine 
• 695-34-1 2-Amino-4-methylpyridine 
• 116241-51-1 C₇H₇FNO₂⁽¹⁺⁾*BF₄^(1-) 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 

Downstream Products

• 369-01-7 2-fluoro-isonicotinic acid amide 
• 369-24-4 2-fluoro-isonicotinic acid hydrazide 
• 1412405-56-1 2-((4-ethyl-5-(2-fluoropyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-isopropylphenyl)acetamide 

Relevant articles and documents

DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES

The application describes dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infection, as well as pharmaceutical or medical applications thereof.

DIRECT FLUORINATION OF SUBSTITUTED PYRIDINES

The direct fluorination of pyridines bearing alkyl, halogen, ester, or ketone functions has been employed to prepare the corresponding 2-fluoro-substituted pyridines.