455-84-5 Usage
Description
4-Fluoro-3-methylbenzoyl chloride is an organic compound with the molecular formula C8H6ClFO. It is a derivative of benzoyl chloride, featuring a fluorine atom at the 4-position and a methyl group at the 3-position. 4-Fluoro-3-methylbenzoyl chloride is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural properties.
Uses
Used in Pharmaceutical Industry:
4-Fluoro-3-methylbenzoyl chloride is used as a key intermediate in the synthesis of various medicinal compositions. Its application is primarily focused on its ability to inhibit p38MAP kinases and/or TNF-α production, which are crucial factors in the development of pain and inflammation.
As a p38MAP Kinase Inhibitor:
4-Fluoro-3-methylbenzoyl chloride is used as a p38MAP kinase inhibitor for the development of pain relief medications. p38MAP kinases are enzymes that play a significant role in the regulation of cellular responses to stress and inflammation. By inhibiting these enzymes, the compound can help reduce the severity of pain and inflammation associated with various conditions.
As a TNF-α Production Inhibitor:
4-Fluoro-3-methylbenzoyl chloride is also used as an inhibitor of TNF-α production. TNF-α, or tumor necrosis factor-alpha, is a cytokine involved in systemic inflammation and is a key player in the pathogenesis of various inflammatory diseases. By inhibiting TNF-α production, the compound can potentially alleviate the symptoms of these diseases and contribute to the development of anti-inflammatory medications.
Check Digit Verification of cas no
The CAS Registry Mumber 455-84-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,5 and 5 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 455-84:
(5*4)+(4*5)+(3*5)+(2*8)+(1*4)=75
75 % 10 = 5
So 455-84-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H6ClFO/c1-5-4-6(8(9)11)2-3-7(5)10/h2-4H,1H3
455-84-5Relevant articles and documents
Palladium-Catalyzed C-H Trifluoroethoxylation of N-Sulfonylbenzamides
Yang, Long,Li, Shangda,Cai, Lei,Ding, Yongzheng,Fu, Lei,Cai, Zhihua,Ji, Huafang,Li, Gang
supporting information, p. 2746 - 2749 (2017/05/24)
The trifluoroethyl aryl ethers are important motifs in drug molecules. However, a report devoted specifically to the study of transition-metal-catalyzed C-H trifluoroethoxylation has not been reported to date. A protocol of Pd(II)-catalyzed o-C-H trifluor
1,2,4 -TRIAZOLES AS ALLOSTERIC MODULATORS OF MGLU5 RECEPTOR ACTIVITY FOR THE TREATMENT OF SCHIZOPHRENIA OF DEMENTIA
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Page/Page column 89, (2013/06/27)
This invention relates to compounds of formula (I) their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, X, R1, R2, R3 have meanings given in the description.
New carboxylic acid amides, the preparation thereof and their use as medicaments
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Page/Page column 42, (2010/02/13)
The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
