4570-45-0 Usage
Description
Oxazole-2-amine is a heterocyclic compound featuring a five-membered ring structure with an oxygen atom and two nitrogen atoms. It is a key building block in the synthesis of various pharmaceuticals and agrochemicals due to its unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
Oxazole-2-amine is used as a chemical reagent for the synthesis of novel inhibitors targeting the kinetoplastid Trypanosoma brucei, a parasitic protozoan responsible for African trypanosomiasis or sleeping sickness. Its incorporation into drug candidates aids in the development of potential treatments for this neglected tropical disease.
Additionally, Oxazole-2-amine can be utilized in the development of other therapeutic agents, given its ability to form stable and bioactive compounds with diverse pharmacological properties. Its presence in a molecule can modulate the activity, selectivity, and pharmacokinetics of drug candidates, making it a valuable component in medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 4570-45-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,5,7 and 0 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 4570-45:
(6*4)+(5*5)+(4*7)+(3*0)+(2*4)+(1*5)=90
90 % 10 = 0
So 4570-45-0 is a valid CAS Registry Number.
InChI:InChI=1/C3H4N2O/c4-3-5-1-2-6-3/h1-2H,(H2,4,5)
4570-45-0Relevant articles and documents
Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation
Fahrenbach, Albert C.,Giurgiu, Constantin,Tam, Chun Pong,Li, Li,Hongo, Yayoi,Aono, Masashi,Szostak, Jack W.
, p. 8780 - 8783 (2017)
We have recently shown that 2-aminoimidazole is a superior nucleotide activating group for nonenzymatic RNA copying. Here we describe a prebiotic synthesis of 2-aminoimidazole that shares a common mechanistic pathway with that of 2-aminooxazole, a previously described key intermediate in prebiotic nucleotide synthesis. In the presence of glycolaldehyde, cyanamide, phosphate and ammonium ion, both 2-aminoimidazole and 2-aminooxazole are produced, with higher concentrations of ammonium ion and acidic pH favoring the former. Given a 1:1 mixture of 2-aminoimidazole and 2-aminooxazole, glyceraldehyde preferentially reacts and cyclizes with the latter, forming a mixture of pentose aminooxazolines, and leaving free 2-aminoimidazole available for nucleotide activation. The common synthetic origin of 2-aminoimidazole and 2-aminooxazole and their distinct reactivities are suggestive of a reaction network that could lead to both the synthesis of RNA monomers and to their subsequent chemical activation.