458-52-6

Basic information

• Product Name: 2-FLUORO-4-METHOXYANILINE
• Synonyms: 2-FLUORO-4-METHOXYANILINE;4-Methoxy-2-fluoroaniline hydrochloride;3-METHOXY-4-FLUOROANILINE,98+%;2-Fluoro-4-methoxyaniline, JRD;(2-fluoro-4-methoxyphenyl)amine(SALTDATA: HCl);(2-fluoro-4-methoxyphenyl)amine 1HCl;2-fluoro-4-MethoxybenzenaMine;4-Fluoro4-Methoxyaniline
• CAS NO: 458-52-6
• Molecular Formula: C₇H₈FNO
• Molecular Weight: 141.14
• Product Categories: Amines;blocks;FluoroCompounds;NULL
• Mol File: 458-52-6.mol
• Article Data: 20

Chemical Properties

• Melting Point: 175°C
• Boiling Point: 203 °C at 760 mmHg
• Flash Point: 76.6 °C
• Appearance: /
• Density: 1.176g/cm³
• Vapor Pressure: 0.284mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.81±0.10(Predicted)
• CAS DataBase Reference: 2-FLUORO-4-METHOXYANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-4-METHOXYANILINE(458-52-6)
• EPA Substance Registry System: 2-FLUORO-4-METHOXYANILINE(458-52-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: 6.1
• Hazardous Substances Data: 458-52-6(Hazardous Substances Data)

Usage

General Description

2-Fluoro-4-methoxyaniline, also known as p-Fluoroanisidine, is a chemical compound with the molecular formula C7H8FNO. It is a derivative of aniline, containing a fluorine atom and a methoxy group attached to the benzene ring. 2-FLUORO-4-METHOXYANILINE is commonly used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of dyes and pigments. It is considered to be a hazardous substance, with potential risks to human health and the environment if not handled and disposed of properly. Therefore, it is important to use this chemical with caution and in accordance with safety guidelines and regulations.

InChI:InChI=1/C7H8FNO/c1-10-5-2-3-7(9)6(8)4-5/h2-4H,9H2,1H3

Upstream product

• 501-58-6 bis(4-methoxyphenyl)diazene 
• 29632-74-4 2-fluro-4-iodoaniline 
• 394-41-2 3-fluoro-4-nitrophenol 
• 372-20-3 3-fluorophenol 
• 394-42-3 2-fluoro-4-methoxy-benzoic acid 
• 217314-30-2 1-(2-fluoro-4-iodophenyl)-2,5-dimethyl-1H-pyrrole 
• 367-24-8 4-bromo-2-fluoroaniline 
• 104-94-9 4-methoxy-aniline 
• 217314-31-3 1-(2-fluoro-4-methoxyphenyl)-2,5-dimethyl-1H-pyrrole 
• 209353-23-1 tert-butyl (2-fluoro-4-methoxyphenyl)carbamate 
• 446-38-8 2-fluoro-4-methoxy-1-nitro-benzene 

Downstream Products

• 394223-28-0 8-fluoro-6-methoxy-quinolin-4-ol 
• 314-12-5 N-(2-fluoro-4-methoxy-phenyl)-phthalimide 
• 827031-30-1 N-(2-fluoro-4-methoxyphenyl)-2-methylquinazolin-4-amine 
• 10205-71-7 4-(6-methoxybenzo[d]thiazol2-yl)-N,N-dimethylaniline 
• 1123636-92-9 6-methoxy-2-(4-methyl-3-nitrophenyl)-1,3-benzothiazole 
• 209353-23-1 tert-butyl (2-fluoro-4-methoxyphenyl)carbamate 
• 774232-76-7 (2,4-dichloro-pyrimidin-5-yl-methyl)-(2-fluoro-4-methoxy-phenyl)amine 
• 39495-33-5 fluoro-[1,4]benzoquinone-1-oxime 
• 146560-55-6 7-((S)-3-Amino-pyrrolidin-1-yl)-6-fluoro-1-(2-fluoro-4-methoxy-phenyl)-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 628686-84-0 2-amino-N-(2-fluoro-4-methoxyphenyl)-4,6-dimethoxybenzamide 
• 458-51-5 2-fluoro-1-iodo-4-methoxybenzene 
• 501-29-1 1-chloro-2-fluoro-4-methoxybenzene 

Relevant articles and documents

Quinoxaline compound, preparation method and application of quinoxaline compound in medicine

The invention provides a quinoxaline compound, a preparation method and application of the quinoxaline compound in medicine, and particularly relates to a quinoxaline compound with PAR4 antagonistic activity, a preparation method of the quinoxaline compound, a pharmaceutical composition containing the quinoxaline compound and application of the quinoxaline compound. Specifically, the invention provides a compound shown as a general formula I and/or II or a tautomer or pharmaceutically acceptable salt thereof, a preparation method of the compound, and application of the compound or the tautomer or the pharmaceutically acceptable salt in medicines for preventing and/or treating thromboembolic diseases.

Benzotriazine compound with PAR4 antagonistic activity and application thereof

The invention discloses a benzotriazine compound with PAR4 antagonistic activity and application thereof. The present invention relates to a compound of formula (I) or a stereoisomer, tautomer, pharmaceutically acceptable salt, ester, solvate or prodrug t

Anion ligand promoted selective C-F bond reductive elimination enables C(sp2)-H fluorination

A detailed mechanism study on the anion ligand promoted selective C-H bond fluorination is reported. The role of the anion ligand has been clarified by experimental evidence and DFT calculations. Moreover, the nitrate promoted C-F bond reductive elimination enabled a selective C-H bond fluorination of various symmetric and asymmetric azobenzenes to access diverse o-fluoroanilines.