460357-62-4

Basic information

• Product Name: 1,2-Cyclohexanediol, 3-methoxy- (9CI)
• Synonyms: 1,2-Cyclohexanediol, 3-methoxy- (9CI)
• CAS NO: 460357-62-4
• Molecular Formula: C7H14O3
• Molecular Weight: 146.18426
• Product Categories: ALCOHOL
• Mol File: 460357-62-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2-Cyclohexanediol, 3-methoxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Cyclohexanediol, 3-methoxy- (9CI)(460357-62-4)
• EPA Substance Registry System: 1,2-Cyclohexanediol, 3-methoxy- (9CI)(460357-62-4)

Safety Data

• Hazardous Substances Data: 460357-62-4(Hazardous Substances Data)

Usage

Derivative of

Cyclohexane

Classification

Alcohol

Synonyms

3-Methoxycyclohexane-1,2-diol

Industrial and commercial applications

a. Fragrance ingredient
b. Solvent
c. Intermediate in the production of other chemicals

Physical state

Clear, colorless liquid

Odor

Slightly sweet

Solubility

Soluble in water

Additional uses

a. Synthesis of pharmaceuticals
b. Synthesis of other organic compounds

Upstream product

• 74-88-4 methyl iodide 
• 2699-17-4 3-methoxy-trans-1,2-epoxycyclohexane 
• 2699-17-4 3-methoxy-cis-1,2-epoxycyclohexane 
• 101254-10-8 (+/-)-2c-acetoxy-1r-methoxy-3t-(toluene-4-sulfonyloxy)-cyclohexane 
• 67-56-1 methanol 
• 1192-78-5 (1R*,2R*,3S*)-2,3-epoxycyclohexanol 
• 101254-10-8 (+/-)-2t-acetoxy-1r-methoxy-3c-(toluene-4-sulfonyloxy)-cyclohexane 

Downstream Products

• 13871-99-3 1,2-Bis-(dimethyl-chlor-siloxy)-3-methoxy-cyclohexan 
• 13871-94-8 1,2-Bis-(trimethyl-silyoxy)-3-methoxy-cyclohexan 

Relevant articles and documents

Eu(OTf)3-Catalyzed highly regioselective nucleophilic ring opening of 2,3-epoxy alcohols: An efficient entry to 3-substituted 1,2-diol derivatives

In our study of the total synthesis of (+)-irciniastatin A, we found a need to develop a method that enables a C3-selective nucleophilic ring opening of 2,3-epoxy alcohol by MeOH, by which we found that the use of combined catalytic amounts of Eu(OTf)3 and 2,6-di-tert-butyl-4-methylpyridine (DTBMP) enables the intended transformation to obtain 3-methoxy-1,2-diol efficiently. Promising features of a protocol that effects a highly regioselective nucleophilic ring opening of 2,3- and 3,4-epoxy alcohols using various nucleophiles including alcohols, thiols, and unprotected amines are described.