461-28-9

Basic information

• Product Name: 3-Fluoro-1-propanesulfonyl chloride
• Synonyms: 3-Fluoro-1-propanesulfonyl chloride;3-Fluoro-propane-1-sulfonyl chloride;3-Fluoropropanesulfonyl chloride;3-fluoropropylsulfurochloridoite
• CAS NO: 461-28-9
• Molecular Formula: C₃H₆ClFO₂S
• Molecular Weight: 160.6
• Mol File: 461-28-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 211℃
• Flash Point: 81℃
• Appearance: /
• Density: 1.385
• Vapor Pressure: 0.163mmHg at 25°C
• Refractive Index: 1.4481
• CAS DataBase Reference: 3-Fluoro-1-propanesulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoro-1-propanesulfonyl chloride(461-28-9)
• EPA Substance Registry System: 3-Fluoro-1-propanesulfonyl chloride(461-28-9)

Safety Data

• Hazardous Substances Data: 461-28-9(Hazardous Substances Data)

Usage

General Description

3-Fluoro-1-propanesulfonyl chloride is a chemical compound with the molecular formula C3H6ClFO2S. It is a clear, colorless liquid that is highly reactive and is primarily used in the synthesis of pharmaceuticals and agrochemicals. It is a sulfonyl chloride derivative, and it is often utilized as a reagent in organic synthesis to introduce the sulfonyl group into various organic molecules. It is also a useful intermediate in the preparation of other compounds, such as sulfonylurea herbicides. It is important to handle this compound with caution, as it can be corrosive and must be stored and handled in a well-ventilated area with appropriate safety equipment.

InChI:InChI=1/C3H6ClFO2S/c4-8(6)7-3-1-2-5/h1-3H2

Upstream product

• 408-00-4 3-fluoropropyl thiocyanate 
• 1033906-64-7 (3-fluoropropyl)ethanethioate 

Downstream Products

• 461-29-0 3-fluoro-propane-1-sulfonyl fluoride 
• 1453200-97-9 N,N-bis(3-fluoropropanesulfonyl)-4-nitroaniline 
• 1453200-94-6 N-(4-nitrophenyl)-3-fluoropropane-1-sulfonamide 
• 1453200-93-5 N-(4-fluorophenyl)-3-fluoropropane-1-sulfonamide 
• 1453200-96-8 N,N-bis(3-fluoropropanesulfonyl)-4-fluoroaniline 
• 1453200-92-4 N-phenyl-3-fluoropropane-1-sulfonamide 
• 1453200-95-7 N,N-bis(3-fluoropropanesulfonyl)aniline 

Relevant articles and documents

QUINAZOLINES AND AZAQUINAZOLINES AS DUAL INHIBITORS OF RAS/RAF/MEK/ERK AND PI3K/AKT/PTEN/MTOR PATHWAYS

The present application provides novel quinazolines and azaquinazolines and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in for co-regulating RAS/RAF/MEK/ERK and PI3K/AKT/PTEN/mTOR pathways by administering a therapeutically effective amount of one or more of the compounds of formula (I), wherein X, Y, T and R4, and R6 to R8' are defined herein, to a patient. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the RAS/RAF/MEK/ERK and PI3K/AKT/PTEN/mTOR pathways. A variety of conditions can be treated using these compounds and include diseases which are characterized by abnormal cellular proliferation. In one embodiment/ the disease is cancer.

CYCLOPROPYL FUSED INDOLOBENZAZEPINE HCV NS5B INHIBITORS

The invention encompasses compounds of formula (I) as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV