461-31-4

Basic information

• Product Name: Methanesulfonic acid 2-fluoroethyl ester
• Synonyms: Methanesulfonic acid 2-fluoroethyl ester;2-fluoroethyl Methanesulfonate
• CAS NO: 461-31-4
• Molecular Formula: C₃H₇FO₃S
• Molecular Weight: 142.1493
• Mol File: 461-31-4.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 242.9°Cat760mmHg
• Flash Point: 100.7°C
• Appearance: /
• Density: 1.281g/cm³
• Vapor Pressure: 0.0516mmHg at 25°C
• Refractive Index: 1.395
• CAS DataBase Reference: Methanesulfonic acid 2-fluoroethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonic acid 2-fluoroethyl ester(461-31-4)
• EPA Substance Registry System: Methanesulfonic acid 2-fluoroethyl ester(461-31-4)

Safety Data

• Hazardous Substances Data: 461-31-4(Hazardous Substances Data)

Usage

General Description

Methanesulfonic acid 2-fluoroethyl ester is a chemical compound with the formula CH3SO3C2H4F. It is an ester derivative of methanesulfonic acid, which is a strong acid commonly used in organic synthesis. The 2-fluoroethyl ester group adds a fluorine atom to the molecule, which can affect the compound's reactivity and properties. This chemical may be used as a reagent in organic synthesis, particularly in the production of pharmaceutical compounds and agrochemicals. It is important to handle this compound with care, as it can be corrosive and harmful if not properly managed. Additionally, it is important to follow all safety guidelines and lab protocols when working with methanesulfonic acid 2-fluoroethyl ester to prevent any accidents or injuries.

InChI:InChI=1/C3H7FO3S/c1-8(5,6)7-3-2-4/h2-3H2,1H3

Upstream product

• 371-62-0 2-fluoroethanol 
• 124-63-0 methanesulfonyl chloride 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1038474-00-8 (S)-methyl 2-[(tert-butoxycarbonyl)amino]-3-[4-(2-fluoroethoxy)phenyl]propanoate 
• 462-31-7 thioacetic acid-2-fluoroethyl ester 
• 1342830-86-7 1-cyclopropyl-3-(3-fluoro-4-(2-(5-((4-(2-fluoroethyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea 
• 1248621-05-7 2-(4-nitrophenyl)-6-(2-fluoroethoxy)benzothiophene 
• 1313378-65-2 N-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-(2-fluoro-ethoxy)-quinolin-6-yl]-acetamide 
• 1245710-91-1 (E)-4-[(2-fluoroethyl)methylamino]-but-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]amide 
• 1137920-98-9 N-t-butoxycarbonyl-4-(3-(2-fluoroethoxy)phenyl)piperazin-1-ylbutanamine 
• 1137920-96-7 N-t-butoxycarbonyl-4-(2-(2-fluoroethoxy)phenyl)piperazin-1-ylbutanamine 
• 820215-85-8 ethyl 3-{4-(2-fluoroethoxy)-3-methoxy-phenyl}propionate 
• 433939-10-7 3-chloro-5-(2-fluoroethoxy)benzaldehyde 
• 947371-47-3 (2S,3S)-2-(N-tert-butoxycarbonyl)amino-3-(3-cyanophenyl)-4-[4-(2-fluoroethoxy)phenyl]butane 

Relevant articles and documents

SUBSTITUTED GUANIDINE COMPOUND

The present invention provides a compound of general formula (I) (wherein X is as described in the present description and claims), or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing that compound.

Nitrogen-containing, fluoroalkyl sulfonyl chloride method for the preparation of (by machine translation)

The invention discloses a nitrogen-containing, fluoroalkyl sulfonyl chloride method for preparing, by containing nitrogen/perfluoroalkyl alcohol as the raw material, under the alkaline condition and a sulfonyl chloride the reaction produces the corresponding nitrogen-containing/perfluoroalkyl sulfonate ester, then nitrogen-containing/perfluoroalkyl sulfonate ester with a thio acetic acid potassium generating affinity substitution reaction to produce the nitrogen-containing/Fluoalkyl thiophosphoro acetate, then the chlorine treatment to obtain nitrogen-containing/fluoroalkyl sulfonyl chloride. The synthesis of this invention containing nitrogen (fluoro) alkyl sulfonyl chloride, the compound is a drug, pesticide research and development and production of important pharmaceutical intermediate, the compound of preparation of the alkyl sulfonyl chloride synthesis of pharmaceutical intermediates database, to the market to provide alkyl sulfonyl chloride can be synthetic fragment. Raw materials used in the present invention chemical reagent is commercially available, low cost, short synthetic route, high yield, high product purity chemical, provides high-purity products, so as to obtain higher economic benefits. (by machine translation)

IMAGING NEURAL ACTIVITY

The present invention provides a novel radiofluorinated compound for imaging voltage-gated sodium channels (VGSCs) that is more straightforward to synthesise than the known radiofluorinated phenoxyphenyl pyrazole carboxylic acid compounds. The compound of the present invention demonstrates specific uptake and retention in key tissues as well as good in vivo stability. Also provided by the present invention is a radiopharmaceutical composition comprising the radiofluorinated compound of the invention, precursor compounds and methods for the synthesis of said radiofluorinated compound, and methods for using said radiofluorinated compound.