461-37-0

Basic information

• Product Name: 2,2,2-TRIFLUOROETHYL CARBAMATE
• Synonyms: Carbamicacid, 2,2,2-trifluoroethyl ester (7CI,8CI); Ethanol, 2,2,2-trifluoro-,carbamate (9CI); 2,2,2-Trifluoroethyl carbamate
• CAS NO: 461-37-0
• Molecular Formula: C₃H₄F₃NO₂
• Molecular Weight: 0
• Mol File: 461-37-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 154.1°Cat760mmHg
• Flash Point: 47°C
• Appearance: /
• Density: 1.407g/cm³
• Vapor Pressure: 3.223mmHg at 25°C
• Refractive Index: 1.347
• CAS DataBase Reference: 2,2,2-TRIFLUOROETHYL CARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-TRIFLUOROETHYL CARBAMATE(461-37-0)
• EPA Substance Registry System: 2,2,2-TRIFLUOROETHYL CARBAMATE(461-37-0)

Safety Data

• Hazardous Substances Data: 461-37-0(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Uses

Intermediate in the synthesis of pharmaceuticals and agrochemicals, solvent and reagent in chemical reactions

Odor

Acrid

Flammability

Highly flammable

Handling precautions

Handle with care and use proper protective equipment.

InChI:InChI=1/C3H4F3NO2/c4-3(5,6)1-9-2(7)8/h1H2,(H2,7,8)

Upstream product

• 110-82-7 cyclohexane 

Downstream Products

• 88809-35-2 8-methyl-1,3-diazaspiro[4.5]decane-2,4-dione 
• 699-51-4 1,3-diazaspiro[4.4]nonane-2,4-dione 
• 346-74-7 N,N'-benzylidene-bis-carbamic acid bis-(2,2,2-trifluoro-ethyl ester) 

Relevant articles and documents

De novo synthesis of troc-protected amines: Intermolecular rhodium-catalyzed C-H amination with N-tosyloxycarbamates

The rhodium-catalyzed intermolecular C-H insertion of the nitrene derived from 2,2,2-trichloroethyl-N-tosyloxycarbamate proceeded in good to excellent yields to produce a variety of Troc-protected amines. With cyclic aliphatic alkanes, it is possible to use only 2 equiv of substrate, whereas the reaction with aromatic alkanes is run neat. Not only does the nitrene insertion proceed in benzylic, secondary, and tertiary C-H bonds but also primary C-H insertion products were obtained in good yields. Finally, the use of chiral rhodium catalysts to provide an enantioselective version of this process is discussed.