461-78-9

Basic information

• Product Name: chlorоphentermine
• Synonyms: chlorоphentermine;4-CHLORPHENTERMINE;2-(4-Chlorobenzyl)-2-propanamine;4-Chloro-α,α-dimethylphenethylamine;p-Chloro-α,α-dimethylbenzeneethanamine;[2-(4-chlorophenyl)-1,1-dimethylethyl]amine hydrochloride;1-(4-chlorophenyl)-2-methylpropan-2-amine;[2-(4-chlorophenyl)-1,1-dimethyl-ethyl]amine
• CAS NO: 461-78-9
• Molecular Formula: C₁₀H₁₄ClN
• Molecular Weight: 183.70
• EINECS: 207-314-9
• Mol File: 461-78-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: bp2 100-102°
• Flash Point: 127°C
• Appearance: /
• Density: 1.0821 (rough estimate)
• Vapor Pressure: 0.016mmHg at 25°C
• Refractive Index: 1.6100 (estimate)
• PKA: pKa 9.60 (Uncertain)
• CAS DataBase Reference: chlorоphentermine(CAS DataBase Reference)
• NIST Chemistry Reference: chlorоphentermine(461-78-9)
• EPA Substance Registry System: chlorоphentermine(461-78-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 461-78-9(Hazardous Substances Data)

Usage

Description

Chlorоphentermine is a potent anorectic drug that belongs to the phenethylamine class of appetite suppressants. It is primarily used to treat obesity by reducing appetite and increasing the feeling of fullness. Chlorоphentermine works by stimulating the central nervous system, specifically the hypothalamus, which is responsible for regulating hunger and satiety.

Uses

Used in Pharmaceutical Industry:
Chlorоphentermine is used as an anorectic agent for the treatment of obesity. It helps in reducing appetite and increasing the feeling of fullness, thus aiding in weight management and promoting a healthier lifestyle.
Used in Weight Loss Products:
Chlorоphentermine is used as an active ingredient in various weight loss products, such as diet pills and supplements. It is often combined with other ingredients to enhance its effectiveness and provide a comprehensive approach to weight management.
Brand Names:
Some of the brand names under which chlorоphentermine is marketed include Pre-Sate (Parke-Davis), Apsedon, Avicol, Avipron, Chenracol, Clorfentermina, Desopimon, Effox, Lucofen Retard, Lucofen SA, Minilip, Phenacon, Reamine, Sinfat, and Teramine. These products are available in different forms, such as tablets, capsules, and liquid solutions, to cater to the varying preferences and needs of consumers.

World Health Organization (WHO)

Chlorphentermine, a sympathomimetic phenethylamine derivative, was introduced over twenty years ago for the treatment of obesity. Concern that its use was associated with cases of pulmonary hypertension led to its withdrawal in several countries. However, it remains available in some other countries.

InChI:InChI=1/C10H14ClN/c1-10(2,12)7-8-3-5-9(11)6-4-8/h3-6H,7,12H2,1-2H3

Upstream product

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Downstream Products

• 1401436-52-9 N-(1-(4-chlorophenyl)-2-methylpropan-2-yl)-4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-amine 
• 1079651-60-7 2-chloro-4-{[2-(4-chlorophenyl)-1,1-dimethylethyl]amino}-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one 
• 80554-87-6 2-methyl-3,3-N-p-(p-chlorophenyl)-α,α-(dimethylethylamino)-ethylindole 
• 101263-55-2 N-Propionyl-1.1-dimethyl-2-<4-chlor-phenyl>-aethylamin 
• 17743-62-3 N-[2-(4-chlorophenyl)-1,1-dimethylethyl]acetamide 
• 100794-43-2 N-Butyryl-1.1-dimethyl-2-<4-chlor-phenyl>-aethylamin 
• 80554-80-9 2-methyl-N-p-(p-chlorophenyl)-α,α-(dimethylethylamino)indole-3-ylglyoxylamide 
• 89516-34-7 1-(2-Acetyl-phenothiazin-10-yl)-2-[2-(4-chloro-phenyl)-1,1-dimethyl-ethylamino]-ethanone 
• 85517-79-9 N-Methylen-4-chloro-α,α-dimethylphenethylamin 
• 85517-92-6 4-Chlor-α,α-dimethylphenethylaminomethyl-N-ethylformamid 
• 29885-38-9 [2-(4-chloro-phenyl)-1,1-dimethyl-ethyl]-(7-nitro-benzo[1,2,5]oxadiazol-4-yl)-amine 
• 5531-31-7 2-cyclohexyl-1,1-dimethyl-ethylamine 

Relevant articles and documents

Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination

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