462-73-7

Basic information

• Product Name: 1-Chloro-4-fluorobutane
• Synonyms: 1-Chloro-4-fluorobutane;1-fluoro-4-chlorobutane
• CAS NO: 462-73-7
• Molecular Formula: C₄H₈ClF
• Molecular Weight: 110.57
• Mol File: 462-73-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 102.4°C (estimate)
• Flash Point: 9.9°C
• Appearance: /
• Density: 1.0627
• Vapor Pressure: 23.3mmHg at 25°C
• Refractive Index: 1.4020
• CAS DataBase Reference: 1-Chloro-4-fluorobutane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-4-fluorobutane(462-73-7)
• EPA Substance Registry System: 1-Chloro-4-fluorobutane(462-73-7)

Safety Data

• Hazardous Substances Data: 462-73-7(Hazardous Substances Data)

Usage

General Description

1-Chloro-4-fluorobutane is a synthetic halogenated compound with the formula C4H8ClF. It exists as a colorless liquid at room temperature and is primarily used in chemical research and in the production of pharmaceuticals. 1-Chloro-4-fluorobutane is chemically reactive due to the presence of both a chlorine and a fluorine atom, making it a versatile reagent. It is generally stored in a cool, dry and well-ventilated place, away from heat sources and open flames. Like many chemical substances, it should be handled under controlled conditions with appropriate personal protective equipment to avoid any potential hazards.

InChI:InChI=1/C4H8ClF/c5-3-1-2-4-6/h1-4H2

Upstream product

• 26910-61-2 4-chlorobutyl methanesulfonate 
• 110-56-5 1,4-dichlorobutane 
• 107-21-1 ethylene glycol 
• 928-51-8 4-Chloro-1-butanol 
• 2366-52-1 1-fluorobutane 
• 6940-78-9 4-chlorobutyl bromide 
• 13617-19-1 1-chloro-4-trimethylsilanyloxy-butane 

Downstream Products

• 353-13-9 5-fluoro-valeronitrile 
• 372-91-8 1-fluoro-4-iodobutane 
• 1019209-49-4 1-[3-(4-fluorobutylamino)-phenyl]-ethanone 
• 373-16-0 6-fluorohex-1-yne 

Relevant articles and documents

REACTIONS OF HALOGEN FLUORIDES. XI. MECHANISM OF REACTIONS OF ALKYL HALIDES WITH BROMINE TRIFLUORIDE

The effects of the substituted halogen, the neighboring groups, and the polarity of the medium on the nature of the fluorination products were studied for the reactions of δ-substituted halogenobutanes and 1,2,3-trihalogenobutanes with bromine tetrachloride.A mechanism involving formation of linear halogenonium ions at the rate-determining stage is proposed.

Free Radical Substitution. Part 37. The Effect of Solvent on the Atomic Chlorination of 1-Substituted Butanes and Related Compounds

Experimental results reported in this paper show that the relative selectivity of atomic chlorination of 1-substituted butanes and related compounds is greatly influenced by the phase and by solvents.Solvents can be divided into three classes: (a) inert, (b) solvents which decrease the selectivity, and (c) solvents which increase the selectivity.The second group solvate the transition state and the third group solvate the chlorine atoms.