46248-01-5

Basic information

• Product Name: 1-BENZENESULFONYLIMIDAZOLE
• Synonyms: 1-BENZENESULFONYLIMIDAZOLE;1-(Phenylsulfonyl)-1H-imidazole;1-(Phenylsulfonyl)imidazole
• CAS NO: 46248-01-5
• Molecular Formula: C₉H₈N₂O₂S
• Molecular Weight: 208.23702
• Mol File: 46248-01-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 75-76 °C
• Boiling Point: 404.4±28.0 °C(Predicted)
• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 1.03±0.10(Predicted)
• CAS DataBase Reference: 1-BENZENESULFONYLIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZENESULFONYLIMIDAZOLE(46248-01-5)
• EPA Substance Registry System: 1-BENZENESULFONYLIMIDAZOLE(46248-01-5)

Safety Data

• Hazardous Substances Data: 46248-01-5(Hazardous Substances Data)

Usage

General Description

1-BENZENESULFONYLIMIDAZOLE is a chemical compound with the formula C14H11N3O2S. It is a derivative of imidazole and contains a benzene ring with a sulfonyl group attached to it. 1-BENZENESULFONYLIMIDAZOLE is used as a building block in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. It has been studied for its potential anti-cancer and anti-inflammatory properties, as well as its ability to inhibit enzymes such as phosphodiesterase. Additionally, 1-BENZENESULFONYLIMIDAZOLE has been investigated for its potential use in the treatment of central nervous system disorders and as a photoactivatable inhibitor of protein tyrosine phosphatases.

Upstream product

• 288-32-4 1H-imidazole 
• 80-17-1 benzenesufonyl hydrazide 
• 108-98-5 thiophenol 
• 368-43-4 phenylsulfonyl fluoride 
• 133745-75-2 N-fluorobis(benzenesulfon)imide 
• 530-62-1 1,1'-carbonyldiimidazole 
• 98-11-3 benzenesulfonic acid 
• 18156-74-6 1-(Trimethylsilyl)imidazole 
• 98-09-9 benzenesulfonyl chloride 

Downstream Products

• 80-17-1 benzenesufonyl hydrazide 
• 2344-70-9 1-phenyl-3-butanol 
• 142841-88-1 1-(benzenesulfonyl)-3-methylimidazolium triflate 
• 95513-28-3 (2R)-trans-1-(phenylsulfonyl)-2-(1-<(phenylsulfonyl)oxy>butyl)-5-heptylpyrrolidine 
• 95513-28-3 (2S)-cis-1-(phenylsulfonyl)-2-(1-<(phenylsulfonyl)oxy>butyl)-5-heptylpyrrolidine 
• 95513-53-4 (2S)-cis-1-(phenylsulfonyl)-5-butyl-2-(1-<(phenylsulfonyl)oxy>heptyl)pyrrolidine 
• 141422-74-4 {2-Benzenesulfonyloxymethyl-3-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-methoxy-4-oxo-azetidin-1-yl}-acetic acid 2-trimethylsilanyl-ethyl ester 

Relevant articles and documents

Synthesis and immunocorrector activity of aromatic sulfonic acid azolides

-

Sulfonamide Synthesis through Electrochemical Oxidative Coupling of Amines and Thiols

Sulfonamides are key motifs in pharmaceuticals and agrochemicals, spurring the continuous development of novel and efficient synthetic methods to access these functional groups. Herein, we report an environmentally benign electrochemical method which enables the oxidative coupling between thiols and amines, two readily available and inexpensive commodity chemicals. The transformation is completely driven by electricity, does not require any sacrificial reagent or additional catalysts and can be carried out in only 5 min. Hydrogen is formed as a benign byproduct at the counter electrode. Owing to the mild reaction conditions, the reaction displays a broad substrate scope and functional group compatibility.

Convenient sulfonylation of imidazoles and triazoles using NFSI

A protocol for the synthesis of N-sulfonyl imidazoles and triazoles has been achieved using N-Fluorobenzenesulfonimide as a sulfonyl source. This reaction proceeded well in the absence of strong bases and catalysts, providing a convenient alternative method for the preparation of N-sulfonyl imidazoles as well as triazoles.