466-07-9

Basic information

• Product Name: NERIIFOLIN
• Synonyms: NERIIFOLIN;digitoxigenin+thevetose;xy)-14-hydroxy-;(3-beta,5-beta)-3-[(6-deoxy-3-O-methyl-alpha-L-glucopyranosyl)oxy]-14-hydroxycard-20(22)-enolide;(5beta)-3beta-[(6-deoxy-3-O-methyl-alpha-L-glucopyranosyl)oxy]-14-hydroxycard-20(22)-enolide;14-Hydroxy-5β-card-20(22)-enolide 3-(6-deoxy-3-O-methyl-α-L-glucopyranoside), 3-([6-Deoxy-3-O-methyl-α-L-glucopyranosyl]oxy)-14-hydroxy-5β-card-20(22)-enolide];(17R)-3β-(3-O-Methyl-6-deoxy-α-L-glucopyranosyloxy)-14-hydroxy-5β,14β-carda-20(22)-enolide;17α-Neriifolin
• CAS NO: 466-07-9
• Molecular Formula: C₃₀H₄₆O₈
• Molecular Weight: 534.68
• EINECS: 207-372-5
• Mol File: 466-07-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 218-225°C
• Boiling Point: 700.1°Cat760mmHg
• Flash Point: 224.9°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: 2-8°C
• Solubility: Chloroform(Slightly), DMSO(Slightly), Methanol (Slightly), Water (Slightly)
• CAS DataBase Reference: NERIIFOLIN(CAS DataBase Reference)
• NIST Chemistry Reference: NERIIFOLIN(466-07-9)
• EPA Substance Registry System: NERIIFOLIN(466-07-9)

Safety Data

• Hazard Codes: T+
• Statements: 26/27/28
• Safety Statements: 22-36/37/39-45
• RIDADR: UN 2811 6.1/PG 1
• WGK Germany: 3
• RTECS: FH4906100
• Hazardous Substances Data: 466-07-9(Hazardous Substances Data)

Usage

Uses

17β-neriifolin could be considered a candidate for the treatment of hepatocellular carcinoma. It can also work as an inhibitor of hERG channel trafficking.

Definition

ChEBI: A cardenolide glycoside that is digitoxigenin in which the hydroxy goup at position 3 has been converted to its (6-deoxy-3-O-methyl-alpha-L-glucopyranoside derivative. Found in the seeds of Cerbera odollamand in Thevetia ahouia and Thevitia neriifolia.

InChI:InChI=1/C30H46O8/c1-16-24(32)26(35-4)25(33)27(37-16)38-19-7-10-28(2)18(14-19)5-6-22-21(28)8-11-29(3)20(9-12-30(22,29)34)17-13-23(31)36-15-17/h13,16,18-22,24-27,32-34H,5-12,14-15H2,1-4H3/t16?,18-,19-,20-,21?,22?,24-,25?,26?,27+,28+,29-,30+/m1/s1

Upstream product

• 25633-33-4 Acetylneriifolin 
• 14364-89-7 Gitoxigenin 3-O-monodigitalosideglucoside, or digitalinum verum 

Relevant articles and documents

CARDIAC GLYCOSIDES FROM THE SEEDS OF Digitalis ciliata

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