Description
Beta-erythroidine, also known as [2R-(2R,13bS)]-2,6,8,9,10,13-hexahydro-2-methoxy-1H,12H-benzo[i]pyrano[3,4-g]indolizin-12-one, is an organic heterotetracyclic indole alkaloid that can be isolated from the seeds and other parts of Erythrina species. It is characterized by its unique structure, where the double bond of the dihydropyranone ring is located beta,
Uses
Used in Pharmaceutical Industry:
Beta-erythroidine is used as a pharmaceutical compound for its potential therapeutic applications. The expression is: beta-erythroidine is used as a therapeutic agent for its unique structural properties and potential medicinal benefits.
Used in Research and Development:
In the field of research and development, beta-erythroidine serves as a valuable compound for studying the chemical properties and biological activities of heterotetracyclic indole alkaloids. The expression is: beta-erythroidine is used as a research compound for understanding its chemical structure and exploring its potential applications in medicine and pharmacology.
Used in Natural Product Chemistry:
Beta-erythroidine is also utilized in the study of natural product chemistry, as it is a naturally occurring compound found in Erythrina species. The expression is: beta-erythroidine is used as a natural product for investigating its role in the biosynthesis and ecological significance of indole alkaloids in plants.
Purification Methods
Purify it like the -isomer but recrystallise it from EtOH. The free base is unstable in air and light, but the hydrochloride is more stable and best stored as such. The methiodide has m 211o (prisms from EtOH). -Erythroidine hydrochloride can be obtained from the -isomeric salt as follows: The -hydrochloride (1.2g) in 10% aqueous NaOH (12mL) is refluxed for 3hours under N2, cooled in ice and conc HCl added to pH 2. After standing for 3hours, NaHCO3 is carefully added to pH 7, the solution is extracted with CHCl3 (5x), and the extracts are dried, filtered, and concentrated to give an oil which on seeding gives -erythroidine m 97-99o. When dissolved in EtOH and dry HCl gas is passed through the solution, the pure -erythroidine hydrochloride crystallises out with m 230.5-231.5o, [ ] D 25 +10o (c 0.5, H2O). It is a muscle relaxant with a curarelikeaction and is more active than the -isomer. [Koniuszy & Folkers J Am Chem Soc 72 519 1950, Boekelheide et al. J Am Chem Soc 75 2550 1953, Boekelheide & Morrison J Am Chem Soc 80 3905 1958, Wenzinger & Boekelheide J Org Chem 29 1307 1964, Berger & Schwartz J Pharmacol Exp Therap 9 3 362 1948, Beilstein 4 IV 3568.]
Check Digit Verification of cas no
The CAS Registry Mumber 466-81-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,6 and 6 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 466-81:
(5*4)+(4*6)+(3*6)+(2*8)+(1*1)=79
79 % 10 = 9
So 466-81-9 is a valid CAS Registry Number.
InChI:InChI=1/C16H19NO3/c1-19-13-3-2-12-5-7-17-6-4-11-10-20-15(18)8-14(11)16(12,17)9-13/h2-3,5,13H,4,6-10H2,1H3/t13-,16-/m0/s1
466-81-9Relevant articles and documents
Total synthesis of (+)-β-erythroidine
Fukumoto, Hironori,Takahashi, Keisuke,Ishihara, Jun,Hatakeyama, Susumi
, p. 2731 - 2734 (2006)
(Chemical Equation Presented) Enyne enyne oh! The first total synthesis of (+)-β-erythroidine, a non-aromatic Erythrina alkaloid, is demonstrated. The key steps involved are Lewis acid promoted cyclization of an epoxy-trichloroacetimidate intermediate and tandem ring-closing metathesis (RCM) of the dienyne (see scheme).
