466-99-9 Usage
Description
Hydromorphone, also known as Dilaudid, is a potent synthetic opioid derivative of morphine. It is approximately five times more potent than morphine and is used primarily in palliative care or for patients who are not opioid-naive. Hydromorphone was introduced in 1926 and is available in various forms, including immediate-release tablets, liquid, and suppositories. A sustained-release form was available but was removed from the U.S. market in 2005 due to safety concerns.
Uses
1. Used in Palliative Care:
Hydromorphone is used as an analgesic agent for severe pain management in palliative care settings. Its high potency makes it a suitable option for patients with severe pain that may not be adequately managed by less potent opioids.
2. Used in Non-Opioid-Naive Patients:
Hydromorphone is used as an alternative opioid for patients who have already been exposed to opioids and may require a more potent medication for effective pain management.
3. Used in Opioid Rotation:
Hydromorphone is used as a part of opioid rotation, a strategy to improve pain control and reduce side effects by switching patients to a different opioid medication.
4. Used in Research and Forensic Applications:
Hydromorphone is used as an analytical reference material categorized as an opioid. It is a metabolite of morphine and is regulated as a Schedule II compound in the United States, making it a valuable tool for research and forensic applications.
5. Used in Immediate-Release Formulations:
Hydromorphone is used in immediate-release tablet, liquid, and suppository forms for the management of moderate to severe pain.
6. Used in Sustained-Release Formulations (outside the United States):
Although the sustained-release form was removed from the U.S. market, it is still available in some countries for the management of chronic pain. However, caution must be exercised due to the potential risks associated with alcohol consumption and the sustained-release formulation.
Biological Functions
Hydromorphone is eight times as potent as morphine
but has less bioavailability following oral administration.
Its side effects do not differ from those of morphine
but are more intense. Hydromorphone is
indicated for use in severe pain and in high doses for relief
of pain in opioid-addicted patients.
Check Digit Verification of cas no
The CAS Registry Mumber 466-99-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,6 and 6 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 466-99:
(5*4)+(4*6)+(3*6)+(2*9)+(1*9)=89
89 % 10 = 9
So 466-99-9 is a valid CAS Registry Number.
InChI:InChI=1/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1
466-99-9Relevant articles and documents
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Weiss,Weiner
, p. 194,195 (1949)
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Method for synthesizing hydromorphone
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Paragraph 0041; 0042; 0043; 0047; 0048; 0049; 0050; 0054, (2018/07/07)
The invention discloses a method for synthesizing hydromorphone by using a continuous flow microchannel reactor. According to the method, by the temperature and the reaction speed of each module of the continuous flow microchannel reactor are controlled, a quenching is integrated into the continuous flow microchannel reactor, and by control of optimal reaction state of hydromorphone synthesis rawmaterials and a catalyst and the reaction speed, the reaction speed is improved. At the same time, through addition of the quenching module, the reaction can be promptly quenched, the precise controlof the reaction time can be achieved, over oxidation in a key step of Oppenauer Oxidation during hydromorphone synthesis can be reduced, production of by-products can be reduced, and reaction yield and hydromorphone product purity can be improved.
NEW PROCESS FOR PREPARING HYDROMORPHONE AND DERIVATIVES THEREOF
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Page/Page column 22; 23; 24; 25; 26; 27; 28; 29; 30, (2017/02/24)
There is provided a novel process for the preparation of a compound of formula (I), wherein R1 is as described in the description, by demethylation of a corresponding O-methyl derivative.
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