4682-36-4 Usage
Description
Orphenadrine citrate is a synthetic anticholinergic agent that acts as a muscle relaxant and antihistamine. It is commonly used to treat muscle spasms and pain caused by various conditions, as well as to alleviate symptoms of allergies.
Uses
Used in Pharmaceutical Industry:
Orphenadrine citrate is used as a muscle relaxant for the treatment of skeletal muscle spasms and pain caused by various conditions, such as muscle strains, sprains, and spasms associated with multiple sclerosis or cerebral palsy.
Orphenadrine citrate is also used as an antihistaminic agent for the relief of symptoms associated with allergies, such as itching, hives, and runny nose.
Additionally, it is used as a histaminergic compound to block the action of acetylcholine, a neurotransmitter responsible for muscle contractions, thus providing relief from muscle spasms and pain.
Originator
Norflex,Riker,US,1959
Manufacturing Process
As described in US Patent 2,567,351, o-methylbenzhydryl bromide is added slowly to β-dimethylaminoethanol at refluxing temperature. After the addition has been completed the mixture is refluxed and stirred for an additional 16 hours. The mixture is cooled and the bottom layer consisting of the crude hydrobromide salt of β-dimethylaminoethanol is drawn off. The excess amino alcohol is distilled from the upper layer in vacuo and the residue is reacted with citric acid.
Therapeutic Function
Muscle relaxant
Clinical Use
Orphenadrine citrate is used for the symptomatic treatment ofParkinson disease. It relieves rigidity better than it doestremor, and in certain cases, it may accentuate the latter. Thedrug combats mental sluggishness, akinesia, adynamia, andlack of mobility, but this effect seems to diminish rather rapidlywith prolonged use. It is best used as an adjunct to theother agents, such as benztropine, procyclidine, cycrimine,and trihexyphenidyl, in the treatment of paralysis agitans.Orphenadrine citrate is also used as an adjunct to rest, physiotherapy,and other measures to relieve pain of local musclespasm (e.g., nocturnal leg cramps).The drug has a low incidence of the usual side effectsfor this group, namely, dryness of mouth, nausea, and mildexcitation.
Check Digit Verification of cas no
The CAS Registry Mumber 4682-36-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,6,8 and 2 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4682-36:
(6*4)+(5*6)+(4*8)+(3*2)+(2*3)+(1*6)=104
104 % 10 = 4
So 4682-36-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H23NO.C6H8O7/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-12,18H,13-14H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
