469-02-3

Basic information

• Product Name: humulon
• Synonyms: humulon;2,4-Cyclohexadien-1-one, 3,5,6-trihydroxy-2,6-bis(3-methyl-2-butenyl)-4-(3-methyl-1-oxobutyl)-;3,5,6-Trihydroxy-4-isovaleryl-2,6-bis(3-methyl-2-butenyl)-2,4-cyclohexadiene-1-one
• CAS NO: 469-02-3
• Molecular Formula: C₂₁H₃₀O₅
• Molecular Weight: 362.4599
• Mol File: 469-02-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 514.4°C at 760 mmHg
• Flash Point: 279°C
• Appearance: /
• Density: 1.121g/cm³
• Vapor Pressure: 9.89E-13mmHg at 25°C
• Refractive Index: 1.53
• CAS DataBase Reference: humulon(CAS DataBase Reference)
• NIST Chemistry Reference: humulon(469-02-3)
• EPA Substance Registry System: humulon(469-02-3)

Safety Data

• Hazardous Substances Data: 469-02-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C21H30O5/c1-12(2)7-8-15-18(23)17(16(22)11-14(5)6)20(25)21(26,19(15)24)10-9-13(3)4/h7,9,14-15,25-26H,8,10-11H2,1-6H3

Relevant articles and documents

Antifungal Activities of Hop Bitter Resins and Related Compounds

Humulone, lupulone and related compounds were found to have antifungal activities.The activities of these compounds were tested to determine their structure-activity relationships.As a result, it was found that the six-membered compounds had antifungal activities against Trichophyton spp., whereas, the five-membered compounds were inactive.Among the compounds tested, 3-isopentenylphlorisovalerophenone 12 showed the highest activity, being almost the same as griseofulvin against Trichophyton spp. 12 also had potent activity against candida, Fusarium, Mucor and Staphylococcus spp.It is suggested that the activity of 12 was significantly affected by the structure of its acyl group.