469-49-8

Basic information

• Product Name: Epigriseofulvin
• Synonyms: (+)-Epigriseofulvin;Epigriseofulvin;Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'R,6'R)-;Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'R-cis)-;Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'α-methyl- (7CI, 8CI);(2R,6'R)-7-Chloro-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione;[2R,(+)]-7-Chloro-2',4,6-trimethoxy-6'β-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione;(2R,5'R)-7-chloro-3',4,6-trimethoxy-5'-methylspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione
• CAS NO: 469-49-8
• Molecular Formula: C₁₇H₁₇ClO₆
• Molecular Weight: 352.76628
• Product Categories: Aromatics
• Mol File: 469-49-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 210-211 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))
• Boiling Point: 570.4±50.0 °C(Predicted)
• Appearance: /
• Density: 1.38±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Stability: Moisture Sensitive
• CAS DataBase Reference: Epigriseofulvin(CAS DataBase Reference)
• NIST Chemistry Reference: Epigriseofulvin(469-49-8)
• EPA Substance Registry System: Epigriseofulvin(469-49-8)

Safety Data

• Hazardous Substances Data: 469-49-8(Hazardous Substances Data)

Usage

Description

Epigriseofulvin is a chemical compound that serves as an important reactant in the synthesis of dl-griseofulvin, an antifungal agent. It plays a crucial role in the production of this medication, which is used to treat various fungal infections.

Uses

Used in Pharmaceutical Industry:
Epigriseofulvin is used as a reactant for the synthesis of dl-griseofulvin, an antifungal agent, for the treatment of various fungal infections. Its role in the production process is essential in creating an effective medication to combat these infections.

Upstream product

• 186581-53-3 diazomethane 
• 469-53-4 (2R,6'R)-7-chloro-4,6-dimethoxy-6'-methyl-spiro[benzofuran-2,1'-cyclohexane]-3,2',4'-trione 
• 67-56-1 methanol 
• 141-52-6 sodium ethanolate 
• 126-07-8 griseofulvin 
• 124-41-4 sodium methylate 
• 17793-63-4 (+)-dihydroepigriseofulvin 
• 7776-77-4 (+/-)-dehydrogriseofulvin 
• 61539-61-5 1,1-dimethoxy-3-trimethylsilyloxy-1,3-butadiene 
• 129529-63-1 (E)-7-chloro-2-ethylidene-4,6-dimethoxy-3(2H)-benzofuranone 
• 3573-90-8 (-)-dehydrogriseofulvin 
• 132692-41-2 7-chloro-4,6-dimethoxy-2-<5-methoxy-1-(methylthio)-3-oxohexylidene>-3(2H)-benzofuranone 
• 26881-62-9 dl-2'-demethoxy-2'-(methylthio)griseofulvin 
• 132692-40-1 5-Methoxy-1,1-bis-methylsulfanyl-hex-1-en-3-one 

Downstream Products

• 126-07-8 griseofulvin 
• 126-07-8 griseofulvin 
• 17793-65-6 (-)-2'-demethoxy-2',3'-dihydroepigriseofulvin 

Relevant articles and documents

Syntheses and antifungal activity of dl-griseofulvin and its congeners. II

Griseofulvin derivatives, dl-6'-demethyl-6'-ethylgriseofulvin (dl-5) and dl-6'-demethyl-6'-phenylgriseofulvin (dl-6) were prepared by application of a synthetic method developed by us. Antifungal activity of these derivatives decreased in the order of dl-

Syntheses and antifungal activities of dl-griseofulvin and its congeners. I

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Microbial transformation of (+)- and (-)-2'-demethoxydehydrogriseofulvin by Streptomyces cinereocrocatus

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