471-95-4 Usage
Description
Bufotaline, also known as Chan Su, is a crystalline genin derived from the Bufo bufo gargarizans, a toad species. It is a potent compound with significant pharmacological properties, making it a valuable substance in the field of medicine.
Uses
Used in Pharmaceutical Industry:
Bufotaline is used as an anti-tumor agent for its ability to inhibit tumor growth and proliferation. It has been found to be effective against various types of cancer, making it a promising candidate for cancer treatment and research.
Used in Traditional Medicine:
In addition to its modern pharmaceutical applications, Bufotaline has also been utilized in traditional medicine practices, where it is believed to possess various therapeutic properties, including its anti-tumor effects.
Used in Drug Development:
Due to its potent anti-tumor properties, Bufotaline is also used in the development of new drugs and therapies for cancer treatment. Researchers are continuously exploring its potential and investigating ways to enhance its efficacy and safety for clinical use.
Hazard
Deadly poison.
Check Digit Verification of cas no
The CAS Registry Mumber 471-95-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,7 and 1 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 471-95:
(5*4)+(4*7)+(3*1)+(2*9)+(1*5)=74
74 % 10 = 4
So 471-95-4 is a valid CAS Registry Number.
InChI:InChI=1/C26H36O6/c1-15(27)32-21-13-26(30)20-6-5-17-12-18(28)8-10-24(17,2)19(20)9-11-25(26,3)23(21)16-4-7-22(29)31-14-16/h4,7,14,17-21,23,28,30H,5-6,8-13H2,1-3H3
471-95-4Relevant articles and documents
Unified Total Synthesis of Five Bufadienolides
Hagiwara, Koichi,Inoue, Masayuki,Itoh, Hiroaki,Shimizu, Shinsuke
, (2020/11/13)
We report a unified total synthesis of five bufadienolides: bufalin (1), bufogenin B (2), bufotalin (3), vulgarobufotoxin (4), and 3-(N-succinyl argininyl) bufotalin (5). After the steroidal ABCD ring 8 was produced, the D ring was cross-coupled with a 2-pyrone moiety and stereoselectively epoxidized to generate 6. TMSOTf promoted a stereospecific 1,2-hydride shift from 6 to establish the β-oriented 2-pyrone of 19. Functional group manipulations from 19 furnished 1-5, which potently inhibited cancer cell growth.