4728-91-0

Basic information

• Product Name: Spiro[4.5]decan-1-one
• CAS NO: 4728-91-0
• Molecular Formula: C10H16O
• Molecular Weight: 152.23
• Mol File: 4728-91-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Spiro[4.5]decan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: Spiro[4.5]decan-1-one(4728-91-0)
• EPA Substance Registry System: Spiro[4.5]decan-1-one(4728-91-0)

Safety Data

• Hazardous Substances Data: 4728-91-0(Hazardous Substances Data)

Upstream product

• 51566-66-6 2-(5-bromopentyl)cyclopentanone 
• 52353-19-2 spiro[4.5]dec‐7‐en‐1‐one 
• 196598-86-4 4-(1-ethoxycarbonyl-cyclohexyl)-butyric acid ethyl ester 
• 56475-47-9 1-(3-iodopropyl)cyclohexanecarbonitrile 
• 77516-45-1 2-<5-(phenylthio)pentyl>cyclopentanone 
• 53545-93-0 1-(3-chloropropyl)cyclohexanecarbonitrile 
• 17347-63-6 Spiro<4.5>decanol-(1) 
• 88729-73-1 1-(3-Trimethylsilanyl-propyl)-cyclohexanecarboxylic acid 
• 4630-82-4 methyl cyclohexylcarboxylate 
• 170161-15-6 1-(1-Phenylsulfanyl-cyclobutyl)-cyclohexanol 
• 152667-68-0 Methyl 1-(3-iodopropyl)cyclohexanecarboxylate 
• 107-32-4 Peroxyformic acid 
• 7125-60-2 1(7)-bicyclo<5.3.0>decene 

Downstream Products

• 17347-63-6 Spiro<4.5>decanol-(1) 
• 30263-80-0 6-phenylspiro[4.5]dec-6-ene 
• 30263-79-7 Phenyl-6-bicyclo<4.4.0>-decen-1 
• 30263-78-6 Phenyl-6-spiro<4.5>decanol-6 
• 7125-60-2 1(7)-bicyclo<5.3.0>decene 

Relevant articles and documents

Relay-Heck Cross-Coupling Between Alkenyl Halides and Unsaturated Alcohols in the Synthesis of Open-Chain Analogues of Musk Odorant Vulcanolide

Unactivated alkenyl iodides and bromides underwent an unprecedented palladium-catalyzed relay-Heck cross-coupling with a whole range of alkenols of different chain lengths linking the alkene and the alcohol, affording unsaturated aldehydes and ketones in moderate to good yields. In contrast, alkenyl triflates were not suitable partners for this reaction. This method allowed the preparation of open-chain analogues of the musk odorant Vulcanolide, several of which retained key olfactory properties of the parent molecule.

Intramolecular Nucleophilic Acyl Substitution Reactions of Halo-Substituted Esters and Lactones. New Applications of Organosamarium Reagents

Intramolecular nucleophilic acyl substitution reactions involving a broad range of halo substituted carboxylic acid derivatives have been accomplished in excellent yield employing samarium(II) iodide as the reductive coupling agent.Although particular substrates cyclized most effectively in THF in the presence of tripiperidinophosphine oxide, carboxylic acid esters, the focus of this report, cyclize equally well without such an additive in the presence of a catalytic quantity of iron(III) complexes.Thus a comprehensive series of halo substituted esters were cyclized in excellent yield to the corresponding 4-, 5-, and 6 -membered carbocycles.The reaction is extremely mild and selective as demonstrated by experiments wherein alkyl chlorides, acetals, and olefins remain completely intact under the reaction conditions.In addition to introducing a convenient procedure for preparing stereodefined spirocyclic systems, a new ring expansion sequence has been developed that appears extremely general for the preparation of various ring systems.

A Cyclopentanone Annulation via Intramolecular Acylation of Alkylsilanes

A facile construction of cyclopentanones is achieved via ring closure of 5-(trimethylsilyl)alkanoyl chlorides under the influence of AlCl3.