4770-23-4

Basic information

• Product Name: 3-benzyl-3-hydroxy-2-methyl-1,3-dihydroisoindol-1(3H)-one
• Synonyms: 3-benzyl-3-hydroxy-2-methyl-1,3-dihydroisoindol-1(3H)-one
• CAS NO: 4770-23-4
• Molecular Weight: 253.301
• Mol File: 4770-23-4.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 3-benzyl-3-hydroxy-2-methyl-1,3-dihydroisoindol-1(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzyl-3-hydroxy-2-methyl-1,3-dihydroisoindol-1(3H)-one(4770-23-4)
• EPA Substance Registry System: 3-benzyl-3-hydroxy-2-methyl-1,3-dihydroisoindol-1(3H)-one(4770-23-4)

Safety Data

• Hazardous Substances Data: 4770-23-4(Hazardous Substances Data)

Upstream product

• 550-44-7 N-methylphthalimide 
• 770-09-2 benzyltrimethylsilane 
• 108-88-3 toluene 
• 100-39-0 benzyl bromide 
• 4702-13-0 N-phthaloylglycine 
• 114-76-1 sodium phenylphyruvate 
• 139232-47-6 potassium L-3-phenyllactate 
• 3700-55-8 2-(2-hydroxypropyl)isoindoline-1,3-dione 
• 103-82-2 phenylacetic acid 
• 13005-36-2 potassium phenylacetate 
• 622-29-7 N-Benzylidenemethylamine 
• 708-14-5 phthalide-3-carboxylic acid 

Downstream Products

• 32003-14-8 4-benzyl-2H-phthalazin-1-one 
• 40523-36-2 (Z)-3-benzylidene-2-methyl-2,3-dihydro-1H-isoindolin-1-one 
• 40523-35-1 (3E)-3-benzylidene-2-methylisoindolin-1-one 

Relevant articles and documents

The Dianion Derived from N-Methylphthalimide

Reduction of N-methylphthalimide with lithium in liquid ammonia provides a stable dianion which has been alkylated with various reagents.

From conventional to microphotochemistry: Photodecarboxylation reactions involving phthalimides

A series of acetone-sensitized photodecarboxylation reactions involving phthalimides have been investigated using conventional and microphotochemistry. Both, intra- and intermolecular transformations were compared. In all cases examined, the reactions performed in microreactors were superior in terms of conversions or isolated yields. These findings unambiguously prove the advantage of microphotochemistry over conventional photochemical techniques.

Intermolecular photodecarboxylation of electron-deficient substrates by phthalimides in water: Efficiency, selectivity and online monitoring

The intermolecular photodecarboxylation of arylacetic acids 3-5 in water by use of stoichiometric amounts of N-alkylated phthalimides 1a,b was investigated by NMR and online pH- and CO2-release sensing. Decreasing the electron donor capability of the arylacetic acids by 4-fluoro and trifluoromethyl substitution alters the efficiency of the photodecarboxylation and selectivity of the secondary reaction. A remarkable switch in reaction channel (A to B) was observed for perfluoropropionic acid.

Synthesis of 4-Alkyl-1(2H)-phthalazinones and 4-Alkyl-2, 3-benzoxazin-1-ones via Ring Cleavage of 3-Substituted N-Alkylated-3-hydroxyisoindolin-1-ones

N-Alkyl (Me, Et, i-Pr, t-Bu)-substituted phthalimdes 5a-d were easily transformed to 1(2H)-phthalazinones 8d-i and 2,3-benzoxazin-1-ones 9d, f, and j via a one-pot addition-decyclization-cyclocondensation process.