4773-13-1Relevant articles and documents
NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF
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Paragraph 468, (2016/09/15)
Described herein are neuroactive steroids of the Formula (I): (I) or a pharmaceutically acceptable salt thereof; wherein R1, R2, Ra, G, X, Y, Z, and n are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. Also provided are pharmaceutical compositions comprising a compound described herein and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
Process for the preparation of leukotriene anatgonists
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, (2008/06/13)
The present invention relates to a process for the preparation of a compound of formula (I) or a sodium salt thereof STR1 wherein HET is 7-chloroquinolin-2-yl or 6,7-difluoroquinolin-2-yl, which comprises: reacting the dilithium dianion of 1-(mercaptomethyl)cyclopropaneacetic acid with a compound of formula (II) STR2 wherein HET is as defined above and L is arylsulfonyl or alkylsulfonyl. The invention further provides the dicyclohexylamine salt of a compound of formula (I).
Preparation of cyclic sulfites by transesterification of diols and diisopropyl sulfite
King, Steven A.,Pipik, Brenda,Conlon, David A.,Bhupathy
, p. 701 - 707 (2007/10/03)
Cyclic sulfites of 1,2-, 1,3- and 1,4-diols can be prepared in high yield by acid or base catalyzed transesterification with diisopropyl sulfite.