4773-96-0 Usage
Description
Mangiferin (MGF) is a natural bioactive polyphenol predominantly isolated from the Mangifera indica (Mango) tree. It has a xanthone glucoside structure and can also be found in other angiosperm plants and herbs. Mangiferin is a yellow powder and is known for its various therapeutic properties.
Uses
1. Used in Pharmaceutical Applications:
Mangiferin is used as a hepatinica and choleretic agent for the therapy of hepatitis. It exhibits anti-inflammatory, antivirotic, and central nervous system inhibiting functions, as well as immunologic suppression.
2. Used in Respiratory Applications:
Mangiferin has a curative effect on chronic bronchitis, providing relief and support for respiratory health.
3. Used in Oncology:
Mangiferin has cytotoxicity effects on hepatocellular carcinoma cells and may induce apoptosis, making it a potential candidate for cancer treatment.
4. Used in Antioxidant Applications:
Mangiferin possesses antioxidant properties, which can help in delaying aging and promoting overall health.
5. Used in Neurological Applications:
Mangiferin acts as a central nervous system inhibitor, which can be beneficial for various neurological conditions.
6. Used in Immune System Applications:
As an immunostimulant, Mangiferin can help boost the immune system and improve overall immune response.
7. Used in MAO Inhibition:
Mangiferin functions as a monoamine oxidase (MAO) inhibitor, which can be useful in treating certain psychiatric and neurological disorders.
Biochem/physiol Actions
Mangiferin has various pharmacological properties including antioxidant, anti-diabetic, anti-bacterial, cardioprotective, neuroprotective, and immunomodulatory activities. It has also displayed antidiabetic, antihyperlipidemic, and antiatherogenic properties in streptozotocin-induced diabetic rats. MGF exerts chemotherapeutic and chemo-preventative activities. It displays antioxidant, analgesic, and hepatoprotective activity against carbon tetrachloride-induced liver injury. MGF is a known accelerator of gastrointestinal transit (GIT).
Check Digit Verification of cas no
The CAS Registry Mumber 4773-96-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,7,7 and 3 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4773-96:
(6*4)+(5*7)+(4*7)+(3*3)+(2*9)+(1*6)=120
120 % 10 = 0
So 4773-96-0 is a valid CAS Registry Number.
InChI:InChI=1/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2/t11-,15-,17+,18-,19?/m1/s1
4773-96-0Relevant articles and documents
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Markham,K.,Wallace,J.
, p. 415 (1980)
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Total synthesis of mangiferin, homomangiferin, and neomangiferin
Wei, Xiong,Liang, Danlin,Wang, Qing,Meng, Xiangbao,Li, Zhongjun
, p. 8821 - 8831 (2016/10/03)
Total synthesis of mangiferin, homomangiferin, and neomangiferin, three C-glycosyl xanthone natural products with a wide spectrum of pharmacological effects, has been achieved starting from 2,3,4,6-tetra-O-benzyl-α/β-d-glucopyranose. The key steps involve a stereoselective Lewis acid promoted C-glycosylation of protected phloroglucinol with tetrabenzylglucopyranosyl acetate and a highly regioselective base-induced cyclization for the construction of the core xanthone skeleton.
Synthesis of mangiferin, isomangiferin, and homomangiferin
Wu, Zhongtao,Wei, Guo,Lian, Gaoyan,Yu, Biao
supporting information; experimental part, p. 5725 - 5728 (2010/10/03)
Mangiferin, isomangiferin, and homomangiferin, the xanthone C-glycosides with a wide spectrum of pharmacological effects, were synthesized concisely, featuring a C-glycosylation of a xanthene derivative with perbenzylglucopyranosyl N-phenyltrifluoroacetimidate.