477326-18-4Relevant articles and documents
Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: Tertiary amides
Chan, Laval,Pereira, Oswy,Reddy, T. Jagadeeswar,Das, Sanjoy K.,Poisson, Carl,Courchesne, Marc,Proulx, Melanie,Siddiqui, Arshad,Yannopoulos, Constantin G.,Nguyen-Ba, Nghe,Roy, Caroline,Nasturica, Daniel,Moinet, Christophe,Bethell, Richard,Hamel, Martine,L'Heureux, Lucille,David, Maud,Nicolas, Olivier,Courtemanche-Asselin, Philippe,Brunette, Stephanie,Bilimoria, Darius,Bedard, Jean
, p. 797 - 800 (2004)
Further SAR studies on the thiophene-2-carboxylic acids are reported. These studies led to the identification of a series of tertiary amides that show inhibition of both HCV NS5B polymerase in vitro and HCV subgenomic RNA replication in Huh-7 cells. Structural insights about the bioactive conformation of this class of molecules were deduced from a combination of modeling and transferred NOE (trNOE) studies.
