48067-24-9Relevant articles and documents
Synthesis of Silacyclic Dipeptides: Peptide Elongation at Both N-And C-Termini of Dipeptide
Hattori, Tomohiro,Yamamoto, Hisashi
supporting information, p. 1758 - 1765 (2022/02/01)
A new type of peptide bond formation utilizing silacyclic amino acids or peptides is described. This work has the following advantages: (1) imidazolylsilane is a highly fascinating coupling reagent for dipeptide synthesis from N-,C-Terminal unprotected am
Heterocyclic derivatives with immunomodulatory effects
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Paragraph 0143; 0151, (2018/03/24)
The invention relates to novel heterocyclic derivatives with immunomodulatory effects capable of inhibiting therapeutic agents in a programmed cell death (PD1) signal path. The compounds disclosed bythe invention are capable of enhancing antitumor activit
Synthesis of analogues of ochratoxin A
Plastina, Pierluigi,Fazio, Alessia,Attya, Mohamed,Sindona, Giovanni,Gabriele, Bartolo
, p. 1799 - 1805 (2020/03/18)
Four analogues of ochratoxin A (OTA) differing for the aminoacidic moiety were synthesised using ochratoxin (OTα) as the starting material. The condensation reaction between protected amino acids and OT, carried out in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC?HCl) and N-hydroxybenzotriazole (HOBt) as coupling agents, followed by deprotection and PTLC purification afforded OTA alanine, leucine, serine and tryptophane analogues in satisfactory yields (33-47%, based on OT).