4810-41-7 Usage
Description
3-N,N-dimethylsulfamoylpyridine is an organic compound with the molecular formula C7H10N2SO. It is an impurity found in Vonaprazan, a novel potassium-competitive acid blocker used for the treatment of acid-related diseases. 3-N,N-dimethylsulfamoylpyridine is characterized by its unique chemical structure, which includes a pyridine ring with a sulfamoyl group and two methyl groups attached to the nitrogen atoms.
Uses
Used in Pharmaceutical Industry:
3-N,N-dimethylsulfamoylpyridine is used as an impurity in the production of Vonaprazan, a novel potassium-competitive acid blocker. Its presence in the final product is crucial for the drug's efficacy in treating acid-related diseases. Vonaprazan works by blocking the potassium channels in the stomach, thereby reducing the production of gastric acid and providing relief from symptoms associated with acid reflux and other acid-related conditions.
In the pharmaceutical industry, the synthesis and purification of Vonaprazan involve the careful control of impurities, such as 3-N,N-dimethylsulfamoylpyridine, to ensure the safety and effectiveness of the final product. The presence of this impurity in controlled amounts does not negatively impact the drug's performance but rather contributes to its overall therapeutic action.
Check Digit Verification of cas no
The CAS Registry Mumber 4810-41-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,1 and 0 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4810-41:
(6*4)+(5*8)+(4*1)+(3*0)+(2*4)+(1*1)=77
77 % 10 = 7
So 4810-41-7 is a valid CAS Registry Number.
4810-41-7Relevant articles and documents
Preparation of sulfonamides from N-silylamines
Naredla, Rajasekhar Reddy,Klumpp, Douglas A.
, p. 5945 - 5947 (2013)
Sulfonamides have been prepared in high yields by the reactions of N-silylamines with sulfonyl chlorides and fluorides. In a competition experiment, the sulfonyl chlorides were found to be far more reactive than sulfonyl fluorides. The chemistry may be used to prepare aliphatic, aromatic, tertiary, secondary, and primary sulfonamides. It may also be done in the absence of solvent and the byproduct trimethylsilyl chloride recovered in good yield. Primary sulfonamides were synthesized from the sulfonyl chloride with aminotriphenyl silane (Ph3SiNH2), a conversion demonstrated with the synthesis of the carbonic anhydrase inhibitor, acetazolamide.
