4847-94-3

Basic information

• Product Name: 1,3-BENZODIOXOLE-5-CARBOXAMIDE
• Synonyms: 1,3-BENZODIOXOLE-5-CARBOXAMIDE;benzo[d][1,3]dioxole-5-carboxamide
• CAS NO: 4847-94-3
• Molecular Formula: C₈H₇NO₃
• Molecular Weight: 165.15
• Mol File: 4847-94-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 283°Cat760mmHg
• Flash Point: 154.4°C
• Appearance: /
• Density: 1.384g/cm³
• Vapor Pressure: 0.00325mmHg at 25°C
• Refractive Index: 1.609
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,3-BENZODIOXOLE-5-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-BENZODIOXOLE-5-CARBOXAMIDE(4847-94-3)
• EPA Substance Registry System: 1,3-BENZODIOXOLE-5-CARBOXAMIDE(4847-94-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 4847-94-3(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 83, p. 1983, 1961 DOI: 10.1021/ja01469a048

InChI:InChI=1/C8H7NO3/c9-8(10)5-1-2-6-7(3-5)12-4-11-6/h1-3H,4H2,(H2,9,10)

Upstream product

• 2089-36-3 piperonal oxime 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 60-29-7 diethyl ether 
• 64-17-5 ethanol 
• 71680-52-9 ammonium cyanide 
• 4720-66-5 Piperil 

Downstream Products

• 145102-05-2 3-<(propylthio)methoxy>-4-hydroxybenzamide 
• 120-57-0 piperonal 
• 82463-74-9 6-Bromo-1,3-benzodioxole-5-carboxamide 
• 15777-84-1 N-methylbenzo[d][1,3]dioxole-5-carboxamide 
• 349114-19-8 N-m-fluorophenyl-3,4-methylenedioxybenzamide 
• 54225-86-4 (3,4-methylenedioxyphenyl) phenyl methanone 
• 1650579-72-8 benzo[d][1,3]dioxol-5-yl(2-phenylaziridin-1-yl)methanone 
• 1616612-93-1 C₃₃H₃₉N₅O₇ 
• 1616612-92-0 C₂₃H₃₀N₄O₄ 
• 1616612-97-5 C₃₅H₄₁N₅O₈ 
• 1616613-00-3 C₄₅H₅₂N₆O₉ 
• 1616613-02-5 C₄₀H₄₇F₃N₆O₉ 
• 1616613-01-4 C₄₅H₅₁N₇O₁₁ 
• 1616612-94-2 C₃₈H₄₈N₆O₈ 

Relevant articles and documents

Stannous chloride dihydrate-mediated efficient access to secondary and primary amides from oximes

Highly selective, efficient and expeditious Beckmann rearrangement of a wide range of ketoximes to secondary amides (20 examples) has been accomplished using stoichiometric amount of stannous chloride dihydrate in the presence of nucleophilic additive, tetra-n-butylammonium iodide (TBAI) (10 moI%) and 4 ? MS in dry acetonitrile at reflux temperature. Aldoximes delivered primary amides through intermediacy of nitriles upon heating with an equimolar amount of SnCl2·2H2O and DBU in dry toluene at reflux in good to acceptable yields (12 examples). Utilization of mild Lewis acid, inexpensive rack reagents and procedural simplicity including easy isolation of products are key advantageous features of the protocol.