487-12-7

Basic information

• Product Name: isoelemicin
• Synonyms: Nsc16705
• CAS NO: 487-12-7
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.25364
• Mol File: 487-12-7.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 306.5°Cat760mmHg
• Flash Point: 102.2°C
• Appearance: /
• Density: 1.028g/cm³
• Vapor Pressure: 0.0014mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: isoelemicin(CAS DataBase Reference)
• NIST Chemistry Reference: isoelemicin(487-12-7)
• EPA Substance Registry System: isoelemicin(487-12-7)

Safety Data

• Hazardous Substances Data: 487-12-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H16O3/c1-5-6-9-7-10(13-2)12(15-4)11(8-9)14-3/h5-8H,1-4H3

Upstream product

• 29652-81-1 1-(3,4,5-trimethoxyphenyl)-1-propanol 
• 487-11-6 elemicin 
• 20675-95-0 (E)-2,6,-dimethoxy-4-(prop-1-en-1-yl)phenol 
• 74-88-4 methyl iodide 
• 41564-88-9 1-(3',4',5'-trimethoxyphenyl)propane 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 123-38-6 propionaldehyde 
• 1530-32-1 ethyltriphenylphosphonium bromide 
• 38059-94-8 (E)-1,2,3-trimethoxy-5-(2-nitroprop-1-enyl)benzene 
• 77-78-1 dimethyl sulfate 
• 195202-06-3 2-ethyl-(3,4,5-trimethoxyphenyl)acetic acid 
• 25245-29-8 5-iodo-1,2,3-trimethoxybenzene 
• 5438-54-0 1,3-dimethoxy-2-[(prop-2-en-1-yl)oxy]benzene 
• 925-90-6 ethylmagnesium bromide 

Downstream Products

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 118-41-2 Eudesmic acid 
• 78111-20-3 (2β,3β,3aα)-3,3a-dihydro-5-methoxy-3-methyl-3a-<3-<(methylsulfonyl)oxy>propyl>-2-(3,4,5-trimethoxyphenyl)-6(2H)-benzofuranone 
• 50393-99-2 (2R*,3R*,4R*,5R*)-2,5-bis(3,4,5-trimethoxyphenyl)-3,4-dimethyltetrahydrofuran 
• 34346-90-2 3-(3',4',5'-trimethoxyphenyl)-prop-2-en-1-al 
• 71277-13-9 3,4,5-trimethoxycinnamaldehyde 
• 657393-37-8 (1S,2S)-1-(3,4,5-trimethoxyphenyl)propane-1,2-diol 
• 657393-24-3 (1R,2R)-1-(3,4,5-trimethoxyphenyl)propane-1,2-diol 
• 658706-64-0 (8R)-oxo-surinamensin 
• 443684-50-2 (2R)-hydroxy-1-(3,4,5-trimethoxy-phenyl)-propan-1-one 
• 657393-38-9 (2S)-hydroxy-1-(3,4,5-trimethoxy-phenyl)-propan-1-one 

Relevant articles and documents

Synthesis, antiepileptic effects, and structure-activity relationships of α-asarone derivatives: In vitro and in vivo neuroprotective effect of selected derivatives

In the present study, we compared the antiepileptic effects of α-asarone derivatives to explore their structure-activity relationships using the PTZ-induced seizure model. Our research revealed that electron-donating methoxy groups in the 3,4,5-position on phenyl ring increased antiepileptic potency but the placement of other groups at different positions decreased activity. Besides, in allyl moiety, the optimal activity was reached with either an allyl or a 1-butenyl group in conjugation with the benzene ring. The compounds 5 and 19 exerted better neuroprotective effects against epilepsy in vitro (cell) and in vivo (mouse) models. This study provides valuable data for further exploration and application of these compounds as potential anti-seizure medicines.

Iron-catalyzed regiodivergent alkyne hydrosilylation

Although tremendous effort has been devoted to the development of methods for iron catalysis, few of the catalysts reported to date exhibit clear superiority to other metal catalysts, and the mechanisms of most iron catalysis remain unclear. Herein, we report that iron complexes bearing 2,9-diaryl-1,10-phenanthroline ligands exhibit not only unprecedented catalytic activity but also unusual ligand-controlled divergent regioselectivity in hydrosilylation reactions of various alkynes. The hydrosilylation protocol described herein provides a highly efficient method for preparing useful di- and trisubstituted olefins on a relatively large scale under mild conditions, and its use markedly improved the synthetic efficiency of a number of bioactive compounds. Mechanistic studies based on control experiments and density functional theory calculations were performed to understand the catalytic pathway and the observed regioselectivity.

Method for synthesizing E-methyl styrene compound

The method for preparing E-pyridyl or alkyl-substituted,bipyridine, in a solvent, in the presence of nitrogen protection, in, reaction 0 °C -50 °C in the presence of a metal nickel salt 24 - 36h, ligand and an additive is E, and the preparation method disclosed by the invention has the advantages, cheap 2,2 ’ - raw materials, easiness in obtaining 2,2 ’ - and the like. The ligand is,bipyridine or an alkyl-substituted bipyridyl compound, in the. presence of a nitrogen, protection agent, in a solvent.