4885-18-1

Basic information

• Product Name: (3-BROMOBENZYL)DIMETHYLAMINE
• Synonyms: 3-(N,N-DIMETHYLAMINOMETHYL)BROMOBENZENE;(3-BROMOBENZYL)DIMETHYLAMINE;(3-BROMOBENZYL)DIMETHYLBENZYLAMINE;1-(3-BROMOPHENYL)-N,N-DIMETHYLMETHANAMINE;(3-Bromophenyl)-N,N-dimethylmethylamine;3-Bromo-N,N-dimethylbenzylamine;BenzeneMethanaMine, 3-broMo-N,N-diMethyl-
• CAS NO: 4885-18-1
• Molecular Formula: C₉H₁₂BrN
• Molecular Weight: 214.1
• Product Categories: Amino;Aryl;Organohalides;alkyl bromide
• Mol File: 4885-18-1.mol
• Article Data: 9

Chemical Properties

• Melting Point: 139-141 °C
• Boiling Point: 227 °C at 760 mmHg
• Flash Point: 91.1 °C
• Appearance: /
• Density: 1.32 g/cm³
• Vapor Pressure: 0.0792mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.71±0.28(Predicted)
• CAS DataBase Reference: (3-BROMOBENZYL)DIMETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (3-BROMOBENZYL)DIMETHYLAMINE(4885-18-1)
• EPA Substance Registry System: (3-BROMOBENZYL)DIMETHYLAMINE(4885-18-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 4885-18-1(Hazardous Substances Data)

Usage

General Description

(3-Bromobenzyl)dimethylamine is a chemical compound that belongs to the class of aromatic amines. It is an organic compound with the molecular formula C9H12BrN and a molar mass of 215.10 g/mol. This chemical is derived from benzylamine, in which one of the hydrogen atoms on the benzene ring is replaced by a bromine atom, and two methyl groups are attached to the amine nitrogen. It is widely used in the pharmaceutical and agrochemical industries as a building block for the synthesis of various biologically active compounds. Additionally, it is utilized as a reagent in organic synthesis to introduce the (3-bromobenzyl)dimethylamino group into different molecules. As a tertiary amine, it exhibits basic properties and can be employed in the production of quaternary ammonium salts and pharmaceuticals.

InChI:InChI=1/C9H12BrN/c1-11(2)7-8-4-3-5-9(10)6-8/h3-6H,7H2,1-2H3

Upstream product

• 124-40-3 dimethyl amine 
• 3132-99-8 m-bromobenzoic aldehyde 
• 100-97-0 hexamethylenetetramine 
• 506-59-2 N,N-dimethylammonium chloride 
• 823-78-9 meta-bromobenzyl bromide 
• 585-76-2 m-bromobenzoic acid 
• 1711-09-7 3-bromobenzoyl chloride 
• 24167-51-9 3-bromo-N,N-dimethylbenzamide 
• 50339-64-5 (isobutoxymethyl)dimethylamine 
• 108-36-1 1,3-dibromobenzene 
• 71323-99-4 (3-bromo-benzyl)-trimethyl-ammonium; bromide 

Downstream Products

• 126631-39-8 α-(6,11-dihydrodibenzothiepin-11-yl)-3-(dimethylaminomethyl)benzyl alcohol 
• 1247001-40-6 (E)-N,N-dimethyl-1-(3-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)phenyl)methanamine 
• 1134206-52-2 AcSCH₂P(C₆H₄-m-CH₂NMe₂)2 
• 1134206-49-7 BH₃*AcSCH₂P(C₆H₄-m-CH₂NMe₂)2 
• 1134206-46-4 BH₃*HP(C₆H₄-m-CH₂NMe₂)2 
• 1401317-94-9 3-(dimethylsilyl)benzyl 3-iodobenzoate 
• 1401317-92-7 3-(dimethylsilyl)benzyl 4-chlorobenzoate 
• 3132-99-8 m-bromobenzoic aldehyde 
• 1134206-43-1 HP(O)(C₆H₄-m-CH₂NMe₂)2 
• 69383-72-8 3-(N,N-Dimethylaminomethyl)benzenemethanol 
• 869846-80-0 (E)-3-(3-dimethylaminomethyl-phenyl)-acrylic acid ethyl ester 

Relevant articles and documents

A Novel Route to Synthesize N,N-Dimethyl Arylmethylamines from Aryl Aldehydes, Hexamethylenetetramine and Hydrogen?

Developing simple and green routes to access valuable chemicals is of significance. Herein, we present a green and novel route to synthesize N,N-dimethyl arylmethylamines (DAMAs) from hexamethylenetetramine (HMTA) and aryl aldehydes in the presence of hydrogen, and a series of DAMAs can be obtained in good yields. This approach opens the precedent for HMTA as N,N-dimethylamine source to synthesize chemicals with N,N-dimethylamine group, which has promising applications for N-containing chemicals synthesis.

Dual antitumor and antiangiogenic activity of organoplatinum(II) complexes

A library of over 20 cycloplatinated compounds of the type [Pt(dmba-R)LCl] (dmba-R = C,N-dimethylbenzylamine-like ligand; R being MeO, Me, H, Br, F, CF3, and NO2 substituents in the R5 or R4 position of the phenyl ring; L = DMSO and P(C6H4CF3-p)3) has been prepared. All compounds are active in both human ovarian carcinoma A2780 cells and cisplatin-resistant A2780cisR cells, with most of the DMSO platinum complexes exhibiting IC50 values in the submicromolar range in the A2780 cell line. Interestingly, DMSO platinum complexes show low cytotoxicity in the nontumorigenic kidney cell line BGM and therefore high selectivity factors SF. In addition, some of the DMSO platinum complexes effectively inhibit angiogenesis in the human umbilical vein endothelial cell line EA.hy926. These are the first platinum(II) complexes reported to inhibit angiogenesis at a close concentration to their IC50 in A2780 cells, turning them into dual cytotoxic and antiangiogenic compounds.

7-(Aryl/heteroaryl-2-ylethynyl)-4-phenylamino-3-quinolinecarbonitriles as new Src kinase inhibitors: Addition of water solubilizing groups

New 4-phenylamino-3-quinolinecarbonitriles with a 7-ethynyl group substituted by a pyridine, phenyl or thiophene ring containing basic water solubilizing groups were prepared and evaluated as Src kinase inhibitors. Of these new analogs, potent activity wa