4945-47-5 Usage
Description
Bamipine, an antihistamine with anticholinergic properties, is a compound derived from the biogenic amine GPCR (G protein-coupled receptor) ligands. It serves as a reagent for dopamine D3 receptor ligands, making it a valuable asset in the field of pharmaceuticals and neuroscience.
Uses
Used in Pharmaceutical Industry:
Bamipine is used as an antihistamine for treating allergic reactions and symptoms such as itching, hives, and rhinitis. Its anticholinergic properties also contribute to its effectiveness in managing various conditions.
Used in Neuroscience Research:
Bamipine is used as a reagent for dopamine D3 receptor ligands, playing a crucial role in the study of dopamine receptors and their involvement in various neurological and psychiatric disorders. This application aids in the development of targeted therapies and a deeper understanding of the underlying mechanisms of these conditions.
Originator
Bamipine,Pharm Chemical
Manufacturing Process
80 g of 1-methyl-piperidone-4 and 70 g of aniline are boiled, using a water
separator in 350 ml of toluene to which several drops of glacial acetic acid
have been added, until the theoretical quantity of water (12.7 ml) has
separated out. The toluene is then distilled off and the remains are
fractionated at reduced pressure. At a boiling point of 156°C/13 mm of Hg
pressure, 118 g of a weakly yellow colored oil of the anil of 1-methyl-1-
piperidone-4 are obtained.
100 g of the above described anil of 1-methyl-1-piperidone-4 are boiled for 8
hours, using a reflux condenser, with 30 g of activated borings of aluminum in
300 ml of methanol diluted with 60 ml of water. The liquid phase is then
separated from the solid phase, the solvent is evaporated and the residuum is
fractionated at reduced pressure, 95 g of a colorless oil being obtained boiling
at 163-165°C at 15 mm of Hg pressure. The oil solidifies at once to a mass of
crystals of 4-N-phenylaimno-1-methylpiperidine. After having been
recrystallized from dibutyl ether the base melts at 87°C, its dihydrochloride
has the melting point of 246°C.
95 g of 4-N-phenylamino-1-methylpiperidine are boiled together with 22 g of
pulverized sodium amide in 300 ml of benzene, using a reflux condenser,
while nitrogen is passed through the reaction mixture, until the evolution of
ammonia has ceased. 64 g of benzyl chloride are then gradually added drop
by drop to the boiling reaction product and boiling is continued for several
hours. After having been cooled the solution is shaken with water and
subsequently dried with potassium carbonate. The solvent having been
evaporated the remaining base of 4-(N-phenyl-N-benzyl)-amino-1-
methylpiperidine solidifies with the formation of crystals, the yield amounting
to 123 g. The base is recrystallized from dibutyl ether and has a melting point
of 115°C; its dihydrochloride melts at 189°C.
Check Digit Verification of cas no
The CAS Registry Mumber 4945-47-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,9,4 and 5 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4945-47:
(6*4)+(5*9)+(4*4)+(3*5)+(2*4)+(1*7)=115
115 % 10 = 5
So 4945-47-5 is a valid CAS Registry Number.
InChI:InChI=1S/C19H24N2/c1-20-14-12-19(13-15-20)21(18-10-6-3-7-11-18)16-17-8-4-2-5-9-17/h2-11,19H,12-16H2,1H3
