494836-60-1

Basic information

• Product Name: methyl α-(2-nitrophenyl)acrylate
• Synonyms: methyl α-(2-nitrophenyl)acrylate
• CAS NO: 494836-60-1
• Molecular Weight: 207.186
• Mol File: 494836-60-1.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: methyl α-(2-nitrophenyl)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl α-(2-nitrophenyl)acrylate(494836-60-1)
• EPA Substance Registry System: methyl α-(2-nitrophenyl)acrylate(494836-60-1)

Safety Data

• Hazardous Substances Data: 494836-60-1(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 30095-98-8 methyl (2-nitrophenyl)acetate 
• 26465-37-2 dimethyl 2-(2-nitrophenyl)malonate 
• 3740-52-1 2-(2-nitrophenyl)acetic acid 
• 1493-27-2 ortho-nitrofluorobenzene 
• 110-88-3 1,3,5-Trioxan 

Downstream Products

• 494836-61-2 1-methyl-3-(2-nitro-phenyl)-pyrrolidine-3-carboxylic acid methyl ester 
• 1105512-95-5 methyl 2-(2-nitrophenyl)-3-(4-methoxycarbonylphenyl)acrylate 
• 1231755-79-5 methyl (2E)-2-(2-nitrophenyl)-3-(4-methoxycarbonylphenyl)acrylate 
• 1231755-82-0 methyl (2E)-2-(2-nitrophenyl)-3-(4-nitrophenyl)acrylate 
• 1231755-81-9 methyl (2E)-2-(2-nitrophenyl)-3-(2-bromophenyl)acrylate 
• 1231755-80-8 methyl (2E)-2-(2-nitrophenyl)-3-(2,4,6-trimethylphenyl)acrylate 
• 1291104-12-5 (4S,5S)-2,2-diethyl 4-methyl 5-(furan-2-yl)-4-(2-nitrophenyl)pyrrolidine-2,2,4-tricarboxylate 
• 1291104-13-6 (4S,5S)-2,2-diethyl 4-methyl 4-(2-nitrophenyl)-5-(thiophen-2-yl)pyrrolidine-2,2,4-tricarboxylate 
• 1291104-06-7 (4S,5R)-2,2-diethyl 4-methyl 4-(2-nitrophenyl)-5-(4-(trifluoromethyl)phenyl)pyrrolidine-2,2,4-tricarboxylate 

Relevant articles and documents

Two concise total syntheses of the wasabi phytoalexin methyl 1-methoxyindole-3-carboxylate

Two new syntheses of the phytoalexin methyl 1-methoxyindole-3-carboxylate (1) were developed that employ the same key intermediate. Methyl 2-(2-nitrophenyl)acrylate (2) was directly converted into phytoalexin 1 using modified Cadogan-Sundberg indole synth

Discovery of 3,3′-Spiro[Azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection

A new series of 3,3′-spirocyclic-2-oxo-indoline derivatives was synthesized and evaluated against respiratory syncytial virus (RSV) in a cell-based assay and animal model. Extensive structure-activity relationship study led to a lead compound 14h, which e

Aqueous Titanium Trichloride Promoted Reductive Cyclization of o-Nitrostyrenes to Indoles: Development and Application to the Synthesis of Rizatriptan and Aspidospermidine

Treatment of o-nitrostyrenes with aqueous TiCl3 solution at room temperature afforded indoles through a formal reductive C(sp2)-H amination process. A range of functions such as halides (Cl, Br), carbonyl (ester, carbamate), cyano, hydroxy, and amino groups were tolerated. From β,β-disubstituted o-nitrostyrenes, 2,3-disubstituted indoles were formed by a domino reduction/cyclization/migration process. Mild conditions, simple experimental procedure, ready accessibility of the starting materials and good to excellent yields characterize the present transformation. The methodology was used as a key step in a concise synthesis of rizatriptan and a formal total synthesis of aspidospermidine. Mild and efficient treatment of o-nitrostyrenes with aqueous TiCl3 solution at room temperature afforded indoles through a formal reductive C(sp2)-Hamination process. A concise synthesis of a marketed drug (rizatriptan) and a formal total synthesis of aspidospermidine featuring this novel N-heterocyclization process are reported.