4962-45-2

Basic information

• Product Name: Benzenemethanol, a-(1-bromoethyl)-
• CAS NO: 4962-45-2
• Molecular Formula: C9H11BrO
• Molecular Weight: 215.09
• Mol File: 4962-45-2.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, a-(1-bromoethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-(1-bromoethyl)-(4962-45-2)
• EPA Substance Registry System: Benzenemethanol, a-(1-bromoethyl)-(4962-45-2)

Safety Data

• Hazardous Substances Data: 4962-45-2(Hazardous Substances Data)

Usage

Synonyms

2-(Bromomethyl)phenyl methanol
1-(Bromomethyl)-2-hydroxybenzene

Physical Properties

Color: Colorless to pale yellow
Odor: Faint
State: Liquid

Primary Uses

Intermediate in pharmaceutical production
Intermediate in dye synthesis
Intermediate in organic compound manufacturing

Function

Acts as a reagent in organic synthesis
Functions as a nucleophile in various reactions

Safety Concerns

Requires careful handling
Potentially hazardous if not used and stored properly

Upstream product

• 93-55-0 1-phenyl-propan-1-one 
• 766-90-5 cis-1-phenyl-1-propylene 
• 2114-36-5 1-bromopropylbenzene 
• 873-66-5 1-propenylbenzene 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 93-54-9 1-Phenyl-1-propanol 
• 637-50-3 1-phenylpropene 
• 1196-45-8 (1-bromoethyl)benzyl bromide 
• 67-64-1 acetone 
• 1196-45-8 (1,2-dibromopropyl)benzene 

Downstream Products

• 4962-46-3 (1RS,2RS)-1-acetoxy-2-bromo-1-phenyl-propane 
• 73568-86-2 (1RS,2RS)-1-hydroxy-1-phenyl-propane-2-sulfonic acid ; sodium-salt 
• 4541-87-1 cis-1-phenylpropene oxide 
• 491-82-7 (+/-)-pseudoisoephedrine 
• 90-82-4 rac-pseudoephedrine 
• 4962-46-3 erythro-1-acetoxy-2-bromo-1-phenylpropane 
• 4962-46-3 threo-1-acetoxy-2-bromo-1-phenylpropane 
• 40626-59-3 (2-Bromo-1-fluoro-propyl)-benzene 
• 40626-59-3 (2-Bromo-1-fluoro-propyl)-benzene 
• 23355-97-7 1-phenylpropylene oxide 
• 54624-37-2 (E)-(2-bromoprop-1-en-1-yl)benzene 
• 21453-89-4 (Z)-(2-bromoprop-1-en-1-yl)benzene 
• 16735-28-7 N-(1-methyl-2-oxo-2-phenylethyl)acetamide 
• 34713-70-7 2-Phenylpropanal 

Relevant articles and documents

Electrochemical bromofunctionalization of alkenes in a flow reactor

The bromination of organic molecules has been extensively studied to date, yet there is still a demand for safe and sustainable methodologies. Hazardous reagents, selectivity, low atom economy and waste production are the most persisting problems of brominating reagents. The electrochemical oxidation of bromide to bromine is a viable strategy to reduce waste by avoiding chemical oxidants. Furthermore, thein situgeneration of reactive intermediates minimizes the risk of hazardous reagents. In this work, we investigate the electrochemical generation of bromine from hydrobromic acid in a flow electrochemical reactor. Various alkenes could be converted to their corresponding dibromides, bromohydrines, bromohydrin ethers and cyclized products in good to excellent yields.

Reaction of Diisobutylaluminum Borohydride, a Binary Hydride, with Selected Organic Compounds Containing Representative Functional Groups

The binary hydride, diisobutylaluminum borohydride [(iBu)2AlBH4], synthesized from diisobutylaluminum hydride (DIBAL) and borane dimethyl sulfide (BMS) has shown great potential in reducing a variety of organic functional groups. This unique binary hydride, (iBu)2AlBH4, is readily synthesized, versatile, and simple to use. Aldehydes, ketones, esters, and epoxides are reduced very fast to the corresponding alcohols in essentially quantitative yields. This binary hydride can reduce tertiary amides rapidly to the corresponding amines at 25 °C in an efficient manner. Furthermore, nitriles are converted into the corresponding amines in essentially quantitative yields. These reactions occur under ambient conditions and are completed in an hour or less. The reduction products are isolated through a simple acid-base extraction and without the use of column chromatography. Further investigation showed that (iBu)2AlBH4 has the potential to be a selective hydride donor as shown through a series of competitive reactions. Similarities and differences between (iBu)2AlBH4, DIBAL, and BMS are discussed.

Catalytic transformation of esters of 1,2-azido alcohols into α-amido ketones

The esters of 1,2-azido alcohols were transformed into α-amido ketones without external oxidants through the Ru-catalyzed formation of N-H imines with the liberation of N2 followed by intramolecular migration of the acyl moiety. A wide range of α-amido ketones were obtained, and one-pot transformation into the corresponding oxazoles (or a thiazole) was demonstrated.