49705-99-9

Basic information

• Product Name: [R-(R*,S*)]-2-amino-3-hydroxybutyramide
• Synonyms: [R-(R*,S*)]-2-amino-3-hydroxybutyramide;(2S,3R)-2-AMino-3-hydroxybutanaMide
• CAS NO: 49705-99-9
• Molecular Formula: C₄H₁₀N₂O₂
• Molecular Weight: 118.1344
• EINECS: 256-437-4
• Mol File: 49705-99-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 384.2°C at 760 mmHg
• Flash Point: 186.2°C
• Appearance: /
• Density: 1.214g/cm³
• Vapor Pressure: 1.74E-07mmHg at 25°C
• Refractive Index: 1.51
• CAS DataBase Reference: [R-(R*,S*)]-2-amino-3-hydroxybutyramide(CAS DataBase Reference)
• NIST Chemistry Reference: [R-(R*,S*)]-2-amino-3-hydroxybutyramide(49705-99-9)
• EPA Substance Registry System: [R-(R*,S*)]-2-amino-3-hydroxybutyramide(49705-99-9)

Safety Data

• Hazardous Substances Data: 49705-99-9(Hazardous Substances Data)

Usage

General Description

[R-(R*,S*)]-2-amino-3-hydroxybutyramide, also known as L-threonine, is a natural amino acid and one of the 20 essential amino acids required for human health. It is an important component of many proteins and is essential for the growth and maintenance of tissues. L-threonine is also involved in the formation of collagen, elastin, and tooth enamel, as well as in the repair of the gastrointestinal tract. It is commonly used as a supplement in animal feed and also has potential therapeutic applications in the treatment of neurological disorders and liver diseases. L-threonine is typically derived from plant or animal sources and has a wide range of industrial and pharmaceutical applications due to its diverse properties and functions in the human body.

InChI:InChI=1/C4H10N2O2/c1-2(7)3(5)4(6)8/h2-3,7H,5H2,1H3,(H2,6,8)

Upstream product

• 3373-59-9 (+/-)-threonine methyl ester hydrochloride 
• 3373-59-9 allo-Thr-OMe 
• 72-19-5 L-threonine 
• 39994-75-7 L-threonine methyl ester hydrochloride 
• 49705-98-8 benzyl ((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)carbamate 
• 3373-59-9 L-threonine methyl ester 

Downstream Products

• 49705-98-8 benzyl ((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)carbamate 
• 1621581-60-9 benzyl 2-(2-(((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)amino)-2-oxoethyl)-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate 
• 1549792-00-8 (2S,3R)-2-((S)-3-(4-chlorophenyl)-N'-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-hydroxybutanamide 
• 1549792-04-2 (2S,3R)-2-((R)-3-(4-chlorophenyl)-N'-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-hydroxybutanamide 
• 33209-01-7 L-threonine amide hydrochloride 
• 80082-49-1 (2S,3R)-3-Hydroxy-2-phenylacetylamino-butyramide 
• 118355-39-8 N-CBZ-L-Tyr-L-Thr-NH₂ 
• 129678-28-0 Bz-Tyr-Thr-NH₂ 
• 126530-15-2 acetyltyrosyl-threonine amide 
• 126530-19-6 acetyltyrozine-glycyl-leucine 
• 80082-48-0 t-butyloxycarbonyl-L-threonine amide 

Relevant articles and documents

Synthesis method of aztreonam main ring synthesis intermediate N-carbobenzoxy-L-threonine amide

The invention provides a synthesis method of aztreonam main ring synthesis intermediate N-carbobenzoxy-L-threonine amide, which comprises the following steps: 1) adding an L-threonine solid and methanol into a reaction kettle, stirring, cooling, dropwisely adding thionyl chloride, carrying out heating reflux reaction, and drying a solvent by distillation; (2) adding methanol into a reactant obtained in the step (1) for dissolving, heating and pressurizing, introducing liquid ammonia, keeping the temperature and the pressure, evaporating the liquid ammonia after the reaction is finished, and evaporating the solvent to dryness; and 3) adding water into a reaction product obtained in the step 2) for dissolving, dropwise adding benzyl chloroformate, dropwise adding an acid-binding agent solution to control the pH value of the reaction system to obtain intermediate N-carbobenzoxy-L-threonine amide, and carrying out filter pressing and drying to obtain a solid.

HEMIAMINAL-TAG FOR PROTEIN LABELING AND PURIFICATION

The invention pertains to the synthesis, isolation, and characterization of hemiaminal for selective labeling of peptides, proteins, antibodies, and organic fragments with -C(=0) CH2NH2 and derivatives with -CH2NH2 group over -C(=0) CHRNH2 group (where R≠H). The invention also pertains to the method of single-site immobilization of proteins through N-terminus Gly on solid phase. The invention includes late-stage tagging of N-terminus Gly with an affinity tag, 19F NMR probe, and a fluorophore and a method for metal-free protein purification and isolation of analytically pure proteins.

PROCESSES FOR SYNTHESIS OF DIPYRROLIDINE PEPTIDE COMPOUNDS

Disclosed is a new process for preparing dipyrrolidine peptide compounds such as, for example, GLYX-13. Advantageously, the process may be industrially scalable and cost-effective and use less toxic reagents and/or solvents. Further, the process may be used to prepare peptide compounds having improved purity.