4978-42-1 Usage
Description
4-Phenoxy-6-oxo-levoMethorphan is a morphinan derivative, which is a type of organic compound that is structurally related to morphine. It is characterized by its brown-orange solid appearance and is primarily used as an intermediate in the preparation of Levomethorphan, a potent antitussive drug.
Uses
Used in Pharmaceutical Industry:
4-Phenoxy-6-oxo-levoMethorphan is used as an intermediate in the synthesis of Levomethorphan for its antitussive properties. Levomethorphan is an effective cough suppressant that acts on the central nervous system to reduce the urge to cough, providing relief for patients suffering from persistent coughing.
Used in Research and Development:
In addition to its pharmaceutical applications, 4-Phenoxy-6-oxo-levoMethorphan may also be utilized in research and development for the study of morphinan derivatives and their potential therapeutic applications. This can include exploring new drug candidates, understanding the structure-activity relationships, and investigating novel methods for drug synthesis and delivery.
Check Digit Verification of cas no
The CAS Registry Mumber 4978-42-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,9,7 and 8 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 4978-42:
(6*4)+(5*9)+(4*7)+(3*8)+(2*4)+(1*2)=131
131 % 10 = 1
So 4978-42-1 is a valid CAS Registry Number.
4978-42-1Relevant articles and documents
Synthesis and pharmacological evaluation of 6,7-indolo/thiazolo-morphinans - Further SAR of levorphanol
Zhang, Ao,Li, Fuying,Ding, Chunyong,Yao, Qizhen,Knapp, Brian I.,Bidlack, Jean M.,Neumeyer, John L.
, p. 2747 - 2751 (2008/02/07)
To further extend the structure-activity relationships of levorphanol, two series of novel morphinans were prepared by incorporation of an indole or aminothiazole fragment to the hexyl ring (ring C) in levorphanol. Such morphinans differed from previously reported ligands in that such indole- or aminothiazole-containing morphinans displayed enhanced binding affinity to the δ opioid receptor, while the affinity to κ and μ receptors was slightly reduced.
