503309-11-3

Basic information

• Product Name: 2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID
• Synonyms: 4-Borono-3-fluorobenzotrifluoride;2-Fluoro-4-(trifluoroMethyl)phenylboronic Acid (contains varying aMounts of Anhydride);4-trifluoroMethyl-2-fluorophenylboronic acid;2-Fluoro-4-(trifluoroMethyl)phenylboronic Acid 2-Fluoro-4-(trifluoroMethyl)boronic acid;Fluoro-4-(trifluoroMethyl)phenylboroni;2-FLUORO-4-(TRIFLUOROMETHYL)BENZENEBORONIC ACID;2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID
• CAS NO: 503309-11-3
• Molecular Formula: C₇H₅BF₄O₂
• Molecular Weight: 207.92
• EINECS: 225-734-0
• Product Categories: blocks;BoronicAcids;Boronic Acid;Aryl;Organoborons
• Mol File: 503309-11-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 113-115°C
• Boiling Point: 251.912 °C at 760 mmHg
• Flash Point: 106.153 °C
• Appearance: /
• Density: 1.443 g/cm³
• Vapor Pressure: 0.01mmHg at 25°C
• Refractive Index: 1.446
• Storage Temp.: 2-8°C
• PKA: 7.62±0.58(Predicted)
• CAS DataBase Reference: 2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID(503309-11-3)
• EPA Substance Registry System: 2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID(503309-11-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22-36
• Safety Statements: 26-36/37/39-36-37
• HazardClass: IRRITANT
• Hazardous Substances Data: 503309-11-3(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

Uses

2-Fluoro-4-trifluoromethylphenylboronic acid

InChI:InChI=1/C7H5BF4O2/c9-6-3-4(7(10,11)12)1-2-5(6)8(13)14/h1-3,13-14H

Upstream product

• 40161-54-4 1-bromo-2-fluoro-4-(trifluoromethyl)benzene 
• 150-46-9 triethyl borate 
• 401-80-9 3-fluoro-trifluoromethylbenzene 
• 121-43-7 Trimethyl borate 
• 5419-55-6 Triisopropyl borate 

Downstream Products

• 1187744-23-5 4-(2-fluoro-4-trifluoromethylphenyl)pyridine-1-oxide 
• 1257875-16-3 5-bromo-2-[2-fluoro-4-(trifluoromethyl)phenyl]pyridine 
• 1349820-97-8 6-butyl-3-(2-fluoro-4-(trifluoromethyl)phenyl)-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one 
• 1160684-44-5 N-({8-[2-fluoro-4-(trifluoromethyl)phenyl]-6-hydroxy-5-quinoxalinyl}carbonyl)glycine 
• 1160685-02-8 N-({7-[2-fluoro-4-(trifluoromethyl)phenyl]-6-hydroxy-5-quinoxalinyl}carbonyl)glycine 
• 1108185-01-8 C₂₅H₂₂F₄N₄O 
• 1251844-21-9 Methyl 2-(2-fluoro-4-(trifluoromethyl)phenyl)isonicotinate hydrochloride 
• 1233697-51-2 6-(2-fluoro-4-(trifluoromethyl)phenyl)pyridazin-3-amine 
• 1220449-49-9 4-[6-(2-fluoro-4-trifluoromethyl-phenyl)-5-nitro-pyrimidin-4-ylamino]-benzenesulfonamide 
• 1220449-45-5 [6-(2-fluoro-4-trifluoromethyl-phenyl)-5-nitro-pyrimidin-4-yl]-(6-methoxy-pyridin-3-yl)-amine 
• 1220449-37-5 [6-(2-fluoro-4-trifluoromethyl-phenyl)-5-nitro-pyrimidin-4-yl]-(4-methoxy-phenyl)-amine 
• 1220449-81-9 4-(2-fluoro-4-trifluoromethyl-phenyl)-6-(4-methoxy-phenoxy)-5-nitro-pyrimidine 
• 1220449-52-4 [6-(2-fluoro-4-trifluoromethyl-phenyl)-5-nitro-pyrimidin-4-yl]-(1H-indol-5-yl)-amine 
• 1187205-73-7 4-chloro-6-(2-fluoro-4-trifluoromethylphenyl)pyrimidin-5-ylamine 

Relevant articles and documents

Preparation method of 2-fluoro-4-(trifluoromethyl) phenylboronic acid

The invention provides a preparation method of 2-fluoro-4-(trifluoromethyl) phenylboronic acid. The preparation method comprises the steps: under the alkaline condition, enabling a first raw material system containing a lithiating agent, boric acid ester and m-fluorobenzotrifluoride reacts to obtain a product system, wherein the product system comprises 2-fluoro-4-trifluoromethyl phenylboronic acid, and the reaction comprises the steps that the m-fluorobenzotrifluoride is subjected to lithiation and boron esterification in sequence. According to the preparation method, the m-fluorobenzotrifluoride is sequentially subjected to lithiation and boron esterification under the alkaline condition, so that by-product impurities and diboric acid impurities which possibly appear originally can be converted into the raw material and the target product respectively, and therefore, the target product can be obtained from the raw material only through two-step reaction, and the preparation method is simple. Moreover, the raw materials used in the invention are low in price, the purity and yield of the reaction product are high, and the target of obtaining the high-yield target product at low cost is effectively achieved.