504-84-7

Basic information

• Product Name: ERYSOLIN
• Synonyms: ERYSOLIN;Erysoline;4-(Methanesulfonyl)butyl isothiocyanate;ERYSOLIN(RG)(PLEASE CALL)
• CAS NO: 504-84-7
• Molecular Formula: C6H11NO2S2
• Molecular Weight: 193.29
• Mol File: 504-84-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 385.5°Cat760mmHg
• Flash Point: 186.9°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 8.44E-06mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: −20°C
• CAS DataBase Reference: ERYSOLIN(CAS DataBase Reference)
• NIST Chemistry Reference: ERYSOLIN(504-84-7)
• EPA Substance Registry System: ERYSOLIN(504-84-7)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-42
• Safety Statements: 26-36/37/39-45
• RIDADR: 1759
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 504-84-7(Hazardous Substances Data)

Usage

Description

ERYSOLIN is an alkaloid derived from various Erythrina species, characterized by its colorless needle-like appearance and a somewhat indefinite melting point with a wide temperature range. It is closely related to erythravine, as the IS-methyl ether of ERYSOLIN is identical to erythravine.

Uses

Used in Pharmaceutical Industry:
ERYSOLIN is used as a chemical enhancer for increasing the amount of daunomycin and vinblastine in PANC-1 cells. This application is particularly relevant in the context of cancer treatment, as it helps improve the effectiveness of these chemotherapeutic drugs against pancreatic cancer.

References

Millington, Steinman, Reinhart, J. Arner. Chern. Soc., 96, 1909 (1974)Hargreaves et al., Lloydia, 37, S69 (1974)

InChI:InChI=1/C6H11NO2S2/c1-11(8,9)5-3-2-4-7-6-10/h2-5H2,1H3

Upstream product

• 463-71-8 thiophosgene 
• 552838-69-4 4-methanesulfonyl-butylamine 
• 27160-24-3 ω-chloro-1-methylsulfanylbutane 
• 4430-36-8 erucin 
• 52096-68-1 2-<2-(Methylthio)butyl>-1H-isoindole-1,3(2H)-dione 
• 84104-30-3 (+/-)-1-amino-4-(methylsulfinyl)butane 
• 59121-24-3 4-(methylthio)butyronitrile 
• 55021-77-7 4-(methylthio)-1-butylamine 
• 4478-93-7 D,L-sulforaphane 

Downstream Products

• 7523-08-2 N-(4-methanesulfonyl-butyl)-N'-phenyl-thiourea 

Relevant articles and documents

4 - methanesulfonyl-butyl isothiocyanate synthetic method (by machine translation)

The invention relates to a 4 - methanesulfonyl-butyl isothiocyanate (Erysolin) chemical synthesis method, the method to 1 - bromo - 4 - chlorobutane, aqueous methyl mercaptan sodium as initial material to synthetic chlorinated thioether, then with the phthalimide potassium salt reaction, to form the tertiary amine combination, continue to hydrazinolysis by thioether primary amine, primary amine in the sulfur phosgene formed under action of the isothiocyanate, final oxidation to obtain Erysolin. The invention provides a method for synthesizing the operation is simple, less dangerous reagent consumption, both cost and yield, is suitable for industrial production of Erysolin synthetic method. (by machine translation)

ISOTHIOCYNATES AND GLUCOSINOLATE COMPOUNDS AND ANTI-TUMOR COMPOSITIONS CONTAINING SAME

The present invention provides glucosinolate and isothiocyanate compounds and related methods for synthesizing these compounds and analogs. In certain embodiments, these glucosinolate and isothiocyanate compounds are useful and chemopreventive and or chemotherapeutic agents.