50700-72-6 Usage
Description
Vecuronium bromide, also known as Norcuron, is a non-depolarizing neuromuscular blocking agent belonging to the class of aminosteroids. It is the monoquaternary analog of pancuronium bromide and is used as an adjunct to general anesthesia to provide skeletal muscle relaxation during surgery or mechanical ventilation. Vecuronium bromide works by competitively binding to the nicotinic cholinergic receptors, preventing the depolarization and release of calcium ions, which in turn stops muscle contraction and promotes muscle relaxation. It is a white solid and is unstable in the presence of acids, undergoing gradual hydrolysis of its ester functions in aqueous solution.
Uses
Used in Anesthesia:
Vecuronium bromide is used as a muscle relaxant during general anesthesia for surgical procedures and mechanical ventilation. It is effective in reducing muscle twitch tension and provides rapid onset (within 4 minutes) with a duration of action lasting up to 4 hours.
Used in Endotracheal Intubation:
Vecuronium bromide is also used to facilitate endotracheal intubation by inducing temporary paralysis and ensuring proper positioning of the endotracheal tube.
Used in Alcohol Antagonist Applications:
Vecuronium bromide can be used as an alcohol antagonist, although this application is not as common as its use in anesthesia.
References
https://en.wikipedia.org/wiki/Vecuronium_bromide
https://www.drugbank.ca/drugs/DB01339
Biological Functions
Vecuronium bromide (Norcuron) is chemically
identical to pancuronium except for a tertiary amine in
place of a quaternary nitrogen. However, some of the
drug will exist as the bisquaternary compound, depending
on body pH. Vecuronium has a moderate onset of
action (2.4 minutes) and a duration of effect of about 50
minutes. Like pancuronium, it does not block ganglia or
vagal neuroeffector junctions, does not release histamine,
and is eliminated by urinary excretion.
Pharmacology
Vecuronium bromide is steroidal agent that was developed in an attempt to
reduce the cardiovascular effects of pancuronium. I t is similar in structure to
the older drug, differing only in the loss of a methyl group from one
quaternary ammonium radical. Thus it is a monoquaternary amine. An intubating dose of 0.1mgkg-1 produces profound neuromuscular block
within 3min. This dose produces clinical block for about 30min. Vecuronium
rarely produces histamine release, nor does it have any direct cardiovascular
effects, although it allows the cardiac effects of other anaesthetic agents, such as bradycardia produced by the opioids, to go unchallenged. Vecuronium is
excreted through the kidneys (30%), although to a lesser extent than
pancuronium, and undergoes hepatic deacetylation; the deacetylated
metabolites have neuromuscular blocking properties. Repeated doses should
be used with care in patients with renal or hepatic disease because they
accumulate.
Clinical Use
Vecuronium Bromide is usedmainly to produce skeletal muscle relaxation during surgeryand to assist in controlled respiration after general anesthesiahas been induced.
Veterinary Drugs and Treatments
Vecuronium is indicated as an adjunct to general anesthesia to produce
muscle relaxation during surgical procedures or mechanical
ventilation and to facilitate endotracheal intubation. It causes very
minimal cardiac effects and generally does not cause the release of
histamine.
Drug interactions
Potentially hazardous interactions with other drugs
Anaesthetics: enhanced muscle relaxant effect.
Anti-arrhythmics: procainamide enhances muscle
relaxant effect.
Antibacterials: effect enhanced by aminoglycosides,
clindamycin, polymyxins and piperacillin.
Antiepileptics: muscle relaxant effects antagonised by
carbamazepine; effects reduced by long-term use of
fosphenytoin and phenytoin but might be increased
by acute use.
Botulinum toxin: neuromuscular block enhanced
(risk of toxicity).
Metabolism
Vecuronium partly metabolised by the liver; the metabolites have some neuromuscular blocking activity. It is excreted mainly in bile as unchanged drug and metabolites; some is also excreted in the urine.
Check Digit Verification of cas no
The CAS Registry Mumber 50700-72-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,7,0 and 0 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 50700-72:
(7*5)+(6*0)+(5*7)+(4*0)+(3*0)+(2*7)+(1*2)=86
86 % 10 = 6
So 50700-72-6 is a valid CAS Registry Number.
InChI:InChI=1/C34H57N2O4.BrH/c1-23(37)39-31-20-25-12-13-26-27(34(25,4)22-29(31)35-16-8-6-9-17-35)14-15-33(3)28(26)21-30(32(33)40-24(2)38)36(5)18-10-7-11-19-36;/h25-32H,6-22H2,1-5H3;1H/q+1;/p-1/t25?,26?,27?,28?,29-,30-,31-,32-,33-,34-;/m0./s1
