50893-53-3 Usage
Description
1-Chloroethyl chloroformate is an organic compound that serves as a versatile reagent in various chemical reactions. It is known for its ability to selectively perform N-dealkylation of tertiary amines, making it a valuable tool in the synthesis of drug metabolites and the analysis of drugs of abuse.
Uses
Used in Forensic Toxicology:
1-Chloroethyl chloroformate is used as a reagent for the N-demethylation of tertiary amines to produce drug metabolite reference material. This application is crucial for forensic toxicological applications, where accurate identification and quantification of drug metabolites are essential for legal proceedings and understanding drug abuse patterns.
Used in Capillary Electrophoresis:
In the field of analytical chemistry, 1-Chloroethyl chloroformate is utilized as a catalyst in the N-demethylation reaction during the determination of multiple drugs of abuse in biological fluids. This process employs capillary electrophoresis with native fluorescence and laser-induced fluorescence detection, allowing for the sensitive and selective analysis of various substances.
Used in Organic Synthesis:
1-Chloroethyl chloroformate is used as a reagent in the chemoselective desilylation of silyl-protected alcohols. This reaction is important in organic synthesis, as it allows for the selective removal of silyl protecting groups under mild conditions, facilitating the synthesis of complex organic molecules.
Used in the Pharmaceutical Industry:
As a reagent for the selective N-dealkylation of tertiary amines, 1-Chloroethyl chloroformate is valuable in the pharmaceutical industry for the synthesis of drug metabolites. This process is essential for understanding the metabolic pathways of drugs and their potential toxicities, as well as for the development of new pharmaceutical agents.
Overall, 1-Chloroethyl chloroformate is a versatile reagent with applications in various fields, including forensic toxicology, analytical chemistry, organic synthesis, and the pharmaceutical industry. Its ability to selectively perform N-dealkylation of tertiary amines and its use in the synthesis of drug metabolites make it an important tool in these areas.
Check Digit Verification of cas no
The CAS Registry Mumber 50893-53-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,8,9 and 3 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 50893-53:
(7*5)+(6*0)+(5*8)+(4*9)+(3*3)+(2*5)+(1*3)=133
133 % 10 = 3
So 50893-53-3 is a valid CAS Registry Number.
InChI:InChI=1/C3H4Cl2O2/c1-2(4)7-3(5)6/h2H,1H3/t2-/m1/s1
50893-53-3Relevant articles and documents
Anti-influenza virus compound as well as preparation method and application thereof
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Paragraph 0131; 0134; 0135, (2021/05/01)
The invention provides an anti-influenza virus pharmaceutical compound, and a preparation method and application thereof. The compound provided by the invention is a prodrug, has remarkably improved bioavailability and antiviral activity compared with a parent drug, is suitable for treating/prepaid influenza virus infection related diseases, has improved pharmacokinetic characteristics, and is particularly suitable for being developed into an oral preparation.
NOVEL BETULINIC ACID DERIVATIVES AS HIV INHIBITORS
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Paragraph 0167, (2013/11/18)
(I)The invention relates to novel novel betulinic acid derivatives and related compounds, and pharmaceutical compositions useful for therapeutic treatment of viral diseases and particularly HIV mediated diseases.
METHOD FOR PRODUCTION OF CANDESARTAN
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Page/Page column 24, (2010/11/08)
The invention relates to novel methods for the production of Candesartan, or a protected form of Candesartan, a Candesartan salt or ester, compounds of application in said method, methods for production thereof, use thereof in said method, a novel polymorph of Candesartan cilexetil, a method for production and use thereof for production of a medicament.
