511-13-7 Usage
Description
2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE is a chemical compound with a complex structure, characterized by its chloro and dimethylaminoethyl groups attached to a benzhydrol core. It is a white crystalline solid and is known for its pharmaceutical applications due to its diverse biological activities.
Uses
Used in Pharmaceutical Industry:
2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE is used as a centrally-acting cough suppressant for its ability to alleviate coughing by acting on the central nervous system. Its local anesthetic properties allow it to numb certain areas, reducing pain and discomfort. Additionally, it possesses antihistamine properties, which can help counteract allergic reactions, and may exhibit anticholinergic effects at high doses, potentially leading to the reduction of certain physiological functions.
Brand Name:
Ulo, marketed by 3M Pharmaceuticals, is a brand name under which 2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE is sold, indicating its commercial availability and use in the medical field.
Originator
Abehol,Pliva
Manufacturing Process
To a suspension of 330.0 g of sodamide (moistened with toluene) in 1500 ml
of absolute ether, a solution of 1080.0 g of o-chlorobenzophenone and 350.0
g of acetonitrile in 3500 ml of absolute ether was gradually added dropwise,
with stirring, such that the reaction temperature adjusted itself to 28°-30°C.
The reaction mixture was stirred for 12 to 15 h at room temperature and was
then added carefully to some ice water. The resulting solution was extracted 3
times with ether. The ether solution was washed with water, dried over
Na2SO4, filtered, and finally concentrated. When 1 L of petroleum ether was
added, 1240.0 g (96% of theoretical) of β-phenyl-β-o-chlorophenylhydroacrylonitrile (melting point 90°-92°C) precipitated.
500.0 g of the β-phenyl-β-o-chlorophenyl-hydroacrylonitrile were dissolved in
3 L of methanol and hydrogenated in the presence of 50.0 g of Raney cobalt
at a temperature of 60°-70°C and a pressure of 80-85 ATM. Two moles of
hydrogen were absorbed, and after separation of the methanolic solution from
the catalyst, 450.0 g of 1-o-chlorophenyl-1-phenyl-3-aminopropanol-1 of
melting point 117°C were obtained.
Catalytic methylation of 1-o-chlorophenyl-1-phenyl-3-aminopropanol-1
(hydrogenation in the presence of 2.2 mol of formaldehyde in aqueous
methanol with Raney nickel catalyst) yielded 450.0 g of l-o-chlorophenyl-1-
phenyl-3 dimethylaminopropanol-1 of melting point 120°C.
In practice it is usually used as hydrochloride.
Therapeutic Function
Antitussive
Check Digit Verification of cas no
The CAS Registry Mumber 511-13-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,1 and 1 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 511-13:
(5*5)+(4*1)+(3*1)+(2*1)+(1*3)=37
37 % 10 = 7
So 511-13-7 is a valid CAS Registry Number.
InChI:InChI=1/C17H20ClNO.ClH/c1-19(2)13-12-17(20,14-8-4-3-5-9-14)15-10-6-7-11-16(15)18;/h3-11,20H,12-13H2,1-2H3;1H
