51328-61-1

Basic information

• Product Name: 2-Amino-2-methyl-1,1-diphenyl-propan-1-ol
• Synonyms: 2-Amino-2-methyl-1,1-diphenyl-propan-1-ol
• CAS NO: 51328-61-1
• Molecular Weight: 241.333
• Mol File: 51328-61-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Amino-2-methyl-1,1-diphenyl-propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-2-methyl-1,1-diphenyl-propan-1-ol(51328-61-1)
• EPA Substance Registry System: 2-Amino-2-methyl-1,1-diphenyl-propan-1-ol(51328-61-1)

Safety Data

• Hazardous Substances Data: 51328-61-1(Hazardous Substances Data)

Upstream product

• 56062-75-0 dimethyl-2,2 diphenyl-3,3 aziridine 
• 16002-63-4 phenylmagnesium iodide 
• 17288-15-2 ethyl 2-aminoisobutyrate hydrochloride 
• 1113-49-1 2-methylalanine ethyl ester 
• 7664-93-9 sulfuric acid 
• 108-86-1 bromobenzene 
• 62-57-7 2-Aminoisobutyric acid 

Downstream Products

• 78077-74-4 2,4,4-Trimethyl-5,5-diphenyl-4,5-dihydro-oxazol 
• 1370293-04-1 3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(1-hydroxy-2-methyl-1,1-diphenylpropan-2-yl)propanamide 
• 1370293-13-2 4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(1-hydroxy-2-methyl-1,1-diphenylpropan-2-yl)butanamide 
• 51328-62-2 2-(9H-Fluoren-9-yl)-2-propanamin 
• 1135085-57-2 C₁₇H₁₇NOS 

Relevant articles and documents

Studies on the asymmetric reduction of β-oximino methyl ether boronates: Reagent control, double diastereocontrol and transmitted remote asymmetric induction

High asymmetric induction (94% ee) could be obtained in the reduction of the achiral E-oxime ether boronate 5 with a homochiral oxazaborolidine 13-BH3-THF complex. Application of this homochiral reducing agent system to non-aromatic oxime ethers 21 produced low to moderate asymmetric induction. Application of the same homochiral reducing agent system to reduction of homochiral boronate E-oximes 3 and 4 produced extreme double diastereo-selection effects, i.e. 8 and 95% ee respectively, which demonstrated that remote asymmetry was being 'transmitted' by a suitable choice of a 'partner' molecule from the boronate moiety to the oxime during reduction. However, attempts to obtain direct remote asymmetric induction in the reduction of homochiral β-oximino boronate methyl ethers 3 and 4 to the corresponding amines produced zero, with for example BH3-THF complex, up to 28% ee with an Et3N-BH3-THF mixture (after oxidative boronate ester cleavage).

The degradation of hydroxyamine derivatives with phosphoric acid

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