518044-32-1 Usage
Description
Hydroxy-PEG-5-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses
Used in Chemical Biology and Medicinal Chemistry:
Hydroxy-PEG-5-t-butyl ester is used as a building block for the synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation.
Used in Bioconjugation:
Hydroxy-PEG-5-t-butyl ester is used as a crosslinker for bioconjugation, allowing the attachment of various molecules to biomolecules such as antibodies or proteins.
Used in Drug Delivery Systems:
Hydroxy-PEG-5-t-butyl ester is used as a component in the development of drug delivery systems, such as antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC molecules) for targeted protein degradation.
Used in Pharmaceutical Industry:
Hydroxy-PEG-5-t-butyl ester is used as a synthetic component in the production of pharmaceuticals, enhancing the solubility and bioavailability of drug molecules.
Used in Research and Development:
Hydroxy-PEG-5-t-butyl ester is used as a versatile reagent in research and development for the creation of novel bioconjugates and drug delivery systems, contributing to the advancement of medical treatments and therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 518044-32-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,1,8,0,4 and 4 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 518044-32:
(8*5)+(7*1)+(6*8)+(5*0)+(4*4)+(3*4)+(2*3)+(1*2)=131
131 % 10 = 1
So 518044-32-1 is a valid CAS Registry Number.
518044-32-1Relevant articles and documents
A new route for the synthesis of 1-amino-3,6,9,12-tetraoxapentadecan-15-oic acid
Wu, Xuan,Zong, Xi,Ji, Min
, p. 368 - 370 (2016)
1-Amino-3,6,9,12-tetraoxapentadecan-15-oic acid 8 was synthesised from tetraethylene glycol through a 7 step sequence including esterification, mesylation, azide substitution with subsequent reduction followed by hydrolysis. The structure of product 8 was
USES OF ANTI-CD3 ANTIBODY FOLATE BIOCONJUGATES
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Paragraph 00357; 00358, (2021/09/03)
Described herein are anti-CD3 antibody folate bioconjugates and uses thereof in the treatment of diseases, conditions, and cancers.
ANTI-CD3 ANTIBODY FOLATE BIOCONJUGATES AND THEIR USES
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Paragraph 00338; 00349; 00350, (2020/03/23)
Described herein are novel anti-CD3 Folate antibodies and uses thereof in the treatment of diseases or conditions that would benefit from such.
